The differential effects of IL-1 and TNF-α on proinflammatory cytokine and matrix metalloproteinase expression in human chondrosarcoma cells

被引：0
|
作者：
J. Shi
E. Schmitt-Talbot
D. A. DiMattia
R. G. Dullea
机构：
[1] Pfizer Global Research and Development,Department of Antibacterial, Immunology, and Inflammation
[2] Pfizer Global Research and Development,Department of Genomic and Proteomic Sciences, MS8118D
[3] Auburn University,3031
来源：
Inflammation Research | 2004年 / 53卷
关键词：
IL-1β; TNF-α; MMP; Chondrocyte; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective and design:Interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs) play important roles in the pathogenesis of osteoarthritis (OA). In the present study, using Affymetrix oligonucleotide array technology and real-time quantitative RT-PCR we have investigated the molecular mechanisms underlying the differential effect of IL-1 and TNF-α on gene expression in the human chondrosarcoma cell line, SW1353.
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页码：377 / 389
页数：12
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