Obtaining a New Gene-Cell Construct Based on Transduced Olfactory Ensheathing Cells for the Treatment of Spinal Cord Injuries

被引：0
|
作者：
A. D. Voronova
A. O. Sosnovtseva
O. V. Stepanova
A. V. Chadin
E. K. Karsuntseva
G. A. Fursa
I. V. Reshetov
V. P. Chekhonin
机构：
[1] Ministry of Health of the Russian Federation,V. P. Serbsky National Medical Research Center for Psychiatry and Narcology
[2] M. V. Lomonosov Moscow State University,University Clinical Hospital No. 1, I. M. Sechenov First Moscow State Medical University
[3] Ministry of Health of the Russian Federation (Sechenov University),National Medical Research Center of Cardiology
[4] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2022年 / 173卷
关键词：
gene-cell therapy; spinal cord injury; olfactory ensheathing cells; brain-derived neurotrophic factor;
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中图分类号：
学科分类号：
摘要：
We developed a viral vector Ad5/35-CAG-mBDNF expressing the mature form of BDNF (mBDNF). On the basis of olfactory ensheathing cells transduced with this adenovector, a new gene-cell construct was obtained. In experiments in vitro, high viability of the transduced olfactory ensheathing cells and enhanced secretion of BDNF by these cells were observed. It is possible that a new gene-cell construct will significantly increase the regenerative effects of transplanted olfactory ensheathing cells.
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页码：529 / 533
页数：4
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