Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes

被引：0

作者：

Yasuteru Urano

Daisuke Asanuma

Yukihiro Hama

Yoshinori Koyama

Tristan Barrett

Mako Kamiya

Tetsuo Nagano

Toshiaki Watanabe

Akira Hasegawa

Peter L Choyke

Hisataka Kobayashi

机构：

[1] Graduate School of Pharmaceutical Sciences,Advanced Core Technology Department, Research and Development Division

[2] The University of Tokyo,undefined

[3] PRESTO,undefined

[4] Japan Science and Technology Agency,undefined

[5] Molecular Imaging Program,undefined

[6] Center for Cancer Research,undefined

[7] National Cancer Institute,undefined

[8] US National Institutes of Health,undefined

[9] Building 10,undefined

[10] Room 1B40,undefined

[11] Mail Stop Code 1088,undefined

[12] Molecular Diagnostic Technology Group,undefined

[13] Olympus Corporation,undefined

[14] 2-3 Kuboyama-cho,undefined

[15] Hachioji,undefined

[16] Present addresses: Department of Radiology,undefined

[17] National Defense Medical College,undefined

[18] 3-2 Namiki,undefined

[19] Tokorozawa,undefined

[20] Saitama 359-8513,undefined

[21] Japan (Y.H.); Department of Diagnostic and Interventional Radiology,undefined

[22] Gunma University Hospital,undefined

[23] 3-39-15 Showa-machi,undefined

[24] Maebashi,undefined

[25] Gunma 371-8511,undefined

[26] Japan (Y.K.); Department of Radiology,undefined

[27] Addenbrooke's Hospital,undefined

[28] Cambridge University Teaching Hospitals National Health Service Foundation Trust,undefined

[29] Hills Road,undefined

[30] Cambridge,undefined

[31] CB2 2QQ,undefined

[32] UK (T.B.).,undefined

来源：

Nature Medicine | 2009年 / 15卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A goal of cancer research is to develop specific and sensitive tumor-imaging techniques for early detection while minimizing background signals from nontarget, 'normal' tissues. The authors have designed a 'pH-activatable' probe, consisting of a targeted macromolecule (monoclonal antibody) and a fluorescence probe, which is activated after internalization in the lysosomes of targeted cancer cells. The utility of this approach for imaging HER2-positive lung cancer cells in mice is shown.

引用

页码：104 / 109

页数：5

共 50 条

[31] ACTIVATABLE SMART PROBES FOR MOLECULAR OPTICAL IMAGING AND THERAPY
Lovell, Jonathan F.
Zheng, Gang
[J]. JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES, 2008, 1 (01) : 45 - 61
[32] A pH-activatable and aniline-substituted photosensitizer for near-infrared cancer theranostics
Tian, Jiangwei
Zhou, Jinfeng
Shen, Zhen
Ding, Lin
Yu, Jun-Sheng
Ju, Huangxian
[J]. CHEMICAL SCIENCE, 2015, 6 (10) : 5969 - 5977
[33] Emerging Designs of Activatable Photoacoustic Probes for Molecular Imaging
Miao, Qingqing
Pu, Kanyi
[J]. BIOCONJUGATE CHEMISTRY, 2016, 27 (12) : 2808 - 2823
[34] pH-Activatable tumor-targeting gold nanoprobe for near-infrared fluorescence/CT dual-modal imaging in vivo
Tang, Yao
Shi, Hongyuan
Cheng, Di
Zhang, Jing
Lin, Yuncheng
Xu, Yufang
Qian, Xuhong
Zhu, Weiping
[J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 179 : 56 - 65
[35] Activatable fluorescent imaging probes for cancer detection and diagnosis
Kobayashi, Hisataka
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
[36] Magnetic nanomaterials with near-infrared pH-activatable fluorescence via iron-catalyzed AGET ATRP for tumor acidic microenvironment imaging
Liu, Xiaodong
Chen, Qian
Yang, Guangbao
Zhang, Lifen
Liu, Zhuang
Cheng, Zhenping
Zhu, Xiulin
[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (14) : 2786 - 2800
[37] Activatable probes for non-invasive small animal fluorescence imaging
Texier, Isabelle
Razkin, Jesus
Josserand, Veronique
Boturyn, Didier
Dumy, Pascal
Coll, Jean-Luc
Rizo, Philippe
[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2007, 571 (1-2): : 165 - 168
[38] Design of a new pH-activatable cell-penetrating peptide for drug delivery into tumor cells
Zhang, Yun
Li, Li
Chang, Linlin
Liu, Hui
Song, Jingjing
Liu, Yue
Bao, Hexin
Liu, Beijun
Wang, Rui
Ni, Jingman
[J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 94 (05) : 1884 - 1893
[39] A pH-Activatable Nanoprobe Labels Diverse Histologic Subtypes of Human Lung Cancer During Resection
Kennedy, Gregory Thomas
Azari, Feredun S.
Chang, Ashley
Chang, Austin
Bou-Samra, Patrick
Desphande, Charuhas
Delikatny, Edward J.
Eruslanov, Evgeniy
Kucharczuk, John C.
Rice, David C.
Singhal, Sunil
[J]. MOLECULAR IMAGING AND BIOLOGY, 2023, 25 (05) : 824 - 832
[40] A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy
Mi, Peng
Kokuryo, Daisuke
Cabral, Horacio
Wu, Hailiang
Terada, Yasuko
Saga, Tsuneo
Aoki, Ichio
Nishiyama, Nobuhiro
Kataoka, Kazunori
[J]. Nature Nanotechnology, 2016, 11 (08) : 724 - +

← 1 2 3 4 5 →