Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes

被引：0

作者：

Yasuteru Urano

Daisuke Asanuma

Yukihiro Hama

Yoshinori Koyama

Tristan Barrett

Mako Kamiya

Tetsuo Nagano

Toshiaki Watanabe

Akira Hasegawa

Peter L Choyke

Hisataka Kobayashi

机构：

[1] Graduate School of Pharmaceutical Sciences,Advanced Core Technology Department, Research and Development Division

[2] The University of Tokyo,undefined

[3] PRESTO,undefined

[4] Japan Science and Technology Agency,undefined

[5] Molecular Imaging Program,undefined

[6] Center for Cancer Research,undefined

[7] National Cancer Institute,undefined

[8] US National Institutes of Health,undefined

[9] Building 10,undefined

[10] Room 1B40,undefined

[11] Mail Stop Code 1088,undefined

[12] Molecular Diagnostic Technology Group,undefined

[13] Olympus Corporation,undefined

[14] 2-3 Kuboyama-cho,undefined

[15] Hachioji,undefined

[16] Present addresses: Department of Radiology,undefined

[17] National Defense Medical College,undefined

[18] 3-2 Namiki,undefined

[19] Tokorozawa,undefined

[20] Saitama 359-8513,undefined

[21] Japan (Y.H.); Department of Diagnostic and Interventional Radiology,undefined

[22] Gunma University Hospital,undefined

[23] 3-39-15 Showa-machi,undefined

[24] Maebashi,undefined

[25] Gunma 371-8511,undefined

[26] Japan (Y.K.); Department of Radiology,undefined

[27] Addenbrooke's Hospital,undefined

[28] Cambridge University Teaching Hospitals National Health Service Foundation Trust,undefined

[29] Hills Road,undefined

[30] Cambridge,undefined

[31] CB2 2QQ,undefined

[32] UK (T.B.).,undefined

来源：

Nature Medicine | 2009年 / 15卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A goal of cancer research is to develop specific and sensitive tumor-imaging techniques for early detection while minimizing background signals from nontarget, 'normal' tissues. The authors have designed a 'pH-activatable' probe, consisting of a targeted macromolecule (monoclonal antibody) and a fluorescence probe, which is activated after internalization in the lysosomes of targeted cancer cells. The utility of this approach for imaging HER2-positive lung cancer cells in mice is shown.

引用

页码：104 / 109

页数：5

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