Genome-wide association study identifies five new schizophrenia loci

被引：0

作者：

机构：

[1] Center for Human Genetic Research,Department of Psychiatry and Behavioral Sciences

[2] Massachusetts General Hospital,Department of Psychiatry and Behavioral Sciences

[3] NorthShore University HealthSystem,Department of Psychiatry

[4] University of Chicago,Department of Human and Molecular Genetics

[5] Virginia Institute for Psychiatric and Behavioral Genetics,Department of Psychiatry and Behavioral Sciences

[6] Virginia Commonwealth University School of Medicine,Department of Psychiatry

[7] Virginia Commonwealth University School of Medicine,Department of Psychological Medicine and Neurology

[8] Virginia Commonwealth University School of Medicine,Department of Biostatistics

[9] Stanford University,Department of Medical Genetics

[10] Mount Sinai School of Medicine,Department of Human Genetics

[11] Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics,Department of Psychiatry

[12] School of Medicine,Department of Genomics

[13] Cardiff University,Research Department of Mental Health Sciences

[14] School of Medicine,Department of Psychiatry

[15] Cardiff University,Division of Psychiatry

[16] University of North Carolina,Department of Psychiatry and Behavioral Science

[17] University Medical Center Utrecht,Department of Non

[18] Rudolf Magnus Institute of Neuroscience,Communicable Disease Epidemiology

[19] University Medical Center Utrecht,Department of Functional Genomics

[20] University of California at Los Angeles (UCLA) Center for Neurobehavioral Genetics,Department of Medical Genomics

[21] University of California at Los Angeles,Department of Psychiatry

[22] University of California at Los Angeles,Department of Clinical Neuroscience

[23] Psychiatry Section,Department of Psychiatry and Psychotherapy

[24] Institute of Clinical Medicine,Department of Medical Genetics

[25] University of Oslo,Department of Research

[26] Oslo University Hospital,Department of Psychiatry and Behavioral Sciences

[27] Broad Institute,Department of Psychiatry and Behavioral Sciences

[28] Life and Brain Center,Department of Psychiatry

[29] University of Bonn,Department of Psychiatry

[30] Institute of Neuroscience and Medicine (INM-1),Department of Psychiatry

[31] Research Center Juelich,Department of Psychiatry

[32] Institute of Human Genetics,Department of Psychiatry

[33] University of Bonn,Department of Psychiatry

[34] Institute of Medical Sciences,Department of Psychiatry

[35] University of Aberdeen,Department of Psychiatry

[36] Neuropsychiatric Genetics Research Group,Department of Medical Genetics

[37] Trinity College Dublin,Department of Statistics

[38] Molecular Psychiatry Laboratory,Department of Psychiatry

[39] University College London Medical School,Department of Clinical Chemistry and Immunology

[40] Windeyer Institute of Medical Sciences,Department of Medical Epidemiology and Biostatistics

[41] Institute of Biological Psychiatry,Department of Child and Adolescent Psychiatry

[42] Mental Health Center (MHC) Sct. Hans,Department of Clinical Pharmacology

[43] Copenhagen University Hospital,Department of Psychology

[44] Molecular and Clinical Neurobiology,Department of Psychiatry and Psychology

[45] Ludwig-Maximilians-University,Department of Genetics

[46] University of Edinburgh,Department of Psychiatry and Behavioral Sciences

[47] Royal Edinburgh Hospital,Department of Psychiatry

[48] Keck School of Medicine,Department of Biostatistics

[49] University of Southern California,Department of Psychiatry

[50] Department of Psychiatry,Department of Mental Health and Substance Abuse Services

来源：

Nature Genetics | 2011年 / 43卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The Schizophrenia Psychiatric Genome-Wide Association Study Consortium reports five genetic loci newly associated with risk of schizophrenia, involving 17,836 cases of schizophrenia and 33,859 healthy controls. The new locus with the strongest support of association was located within an intron for microRNA 137, a known regulator of neuronal development. Four other genome-wide significant loci for schizophrenia contain predicted targets of MIR137, suggesting that disruption to pathways involving MIR137 may be an etiologic mechanism in schizophrenia.

引用

页码：969 / 976

页数：7

共 50 条

[1] Genome-wide association study identifies five new schizophrenia loci
Meera Swami
[J]. Nature Medicine, 2011, 17 (10) : 1199 - 1199
[2] Genome-wide association study identifies five new schizophrenia loci
Ripke, Stephan
Sanders, Alan R.
Kendler, Kenneth S.
Levinson, Douglas F.
Sklar, Pamela
Holmans, Peter A.
Lin, Dan-Yu
Duan, Jubao
Ophoff, Roel A.
Andreassen, Ole A.
Scolnick, Edward
Cichon, Sven
Clair, David St.
Corvin, Aiden
Gurling, Hugh
Werge, Thomas
Rujescu, Dan
Blackwood, Douglas H. R.
Pato, Carlos N.
Malhotra, Anil K.
Purcell, Shaun
Dudbridge, Frank
Neale, Benjamin M.
Rossin, Lizzy
Visscher, Peter M.
Posthuma, Danielle
Ruderfer, Douglas M.
Fanous, Ayman
Stefansson, Hreinn
Steinberg, Stacy
Mowry, Bryan J.
Golimbet, Vera
De Hert, Marc
Jonsson, Erik G.
Bitter, Istvan
Pietilainen, Olli P. H.
Collier, David A.
Tosato, Sarah
Agartz, Ingrid
Albus, Margot
Alexander, Madeline
Amdur, Richard L.
Amin, Farooq
Bass, Nicholas
Bergen, Sarah E.
Black, Donald W.
Borglum, Anders D.
Brown, Matthew A.
Bruggeman, Richard
Buccola, Nancy G.
[J]. NATURE GENETICS, 2011, 43 (10) : 969 - 976
[3] Genome-wide association study identifies five susceptibility loci for glioma
Sanjay Shete
Fay J Hosking
Lindsay B Robertson
Sara E Dobbins
Marc Sanson
Beatrice Malmer
Matthias Simon
Yannick Marie
Blandine Boisselier
Jean-Yves Delattre
Khe Hoang-Xuan
Soufiane El Hallani
Ahmed Idbaih
Diana Zelenika
Ulrika Andersson
Roger Henriksson
A Tommy Bergenheim
Maria Feychting
Stefan Lönn
Anders Ahlbom
Johannes Schramm
Michael Linnebank
Kari Hemminki
Rajiv Kumar
Sarah J Hepworth
Amy Price
Georgina Armstrong
Yanhong Liu
Xiangjun Gu
Robert Yu
Ching Lau
Minouk Schoemaker
Kenneth Muir
Anthony Swerdlow
Mark Lathrop
Melissa Bondy
Richard S Houlston
[J]. Nature Genetics, 2009, 41 : 899 - 904
[4] Genome-wide association study identifies five new breast cancer susceptibility loci
Clare Turnbull
Shahana Ahmed
Jonathan Morrison
David Pernet
Anthony Renwick
Mel Maranian
Sheila Seal
Maya Ghoussaini
Sarah Hines
Catherine S Healey
Deborah Hughes
Margaret Warren-Perry
William Tapper
Diana Eccles
D Gareth Evans
Maartje Hooning
Mieke Schutte
Ans van den Ouweland
Richard Houlston
Gillian Ross
Cordelia Langford
Paul D P Pharoah
Michael R Stratton
Alison M Dunning
Nazneen Rahman
Douglas F Easton
[J]. Nature Genetics, 2010, 42 : 504 - 507
[5] Genome-Wide Association Study Identifies Five New Loci Associated With Lung Function
Repapi, E.
Sayers, I.
Wain, L. V.
Obeidat, M.
Elliott, P.
Strachan, D. P.
Hall, I. P.
Tobin, M. D.
Consortium, SpiroMeta
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181
[6] Genome-wide association study identifies five susceptibility loci for glioma
Shete, Sanjay
Hosking, Fay J.
Robertson, Lindsay B.
Dobbins, Sara E.
Sanson, Marc
Malmer, Beatrice
Simon, Matthias
Marie, Yannick
Boisselier, Blandine
Delattre, Jean-Yves
Hoang-Xuan, Khe
El Hallani, Soufiane
Idbaih, Ahmed
Zelenika, Diana
Andersson, Ulrika
Henriksson, Roger
Bergenheim, A. Tommy
Feychting, Maria
Lonn, Stefan
Ahlbom, Anders
Schramm, Johannes
Linnebank, Michael
Hemminki, Kari
Kumar, Rajiv
Hepworth, Sarah J.
Price, Amy
Armstrong, Georgina
Liu, Yanhong
Gu, Xiangjun
Yu, Robert
Lau, Ching
Schoemaker, Minouk
Muir, Kenneth
Swerdlow, Anthony
Lathrop, Mark
Bondy, Melissa
Houlston, Richard S.
[J]. NATURE GENETICS, 2009, 41 (08) : 899 - U54
[7] Genome-wide association study identifies five new breast cancer susceptibility loci
Turnbull, Clare
Ahmed, Shahana
Morrison, Jonathan
Pernet, David
Renwick, Anthony
Maranian, Mel
Seal, Sheila
Ghoussaini, Maya
Hines, Sarah
Healey, Catherine S.
Hughes, Deborah
Warren-Perry, Margaret
Tapper, William
Eccles, Diana
Evans, D. Gareth
Hooning, Maartje
Schutte, Mieke
van den Ouweland, Ans
Houlston, Richard
Ross, Gillian
Langford, Cordelia
Pharoah, Paul D. P.
Stratton, Michael R.
Dunning, Alison M.
Rahman, Nazneen
Easton, Douglas F.
[J]. NATURE GENETICS, 2010, 42 (06) : 504 - U47
[8] Genome-wide association study identifies five new cadmium uptake loci in wheat
Bin Safdar, Luqman
Almas, Fakhrah
Sarfraz, Sidra
Ejaz, Muhammad
Ali, Zeshan
Mahmood, Zahid
Yang, Li
Tehseen, Muhammad Massub
Ikram, Muhammad
Liu, Shengyi
Quraishi, Umar Masood
[J]. PLANT GENOME, 2020, 13 (02):
[9] Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Ripke, Stephan
O'Dushlaine, Colm
Chambert, Kimberly
Moran, Jennifer L.
Kaehler, Anna K.
Akterin, Susanne
Bergen, Sarah E.
Collins, Ann L.
Crowley, James J.
Fromer, Menachem
Kim, Yunjung
Lee, Sang Hong
Magnusson, Patrik K. E.
Sanchez, Nick
Stahl, Eli A.
Williams, Stephanie
Wray, Naomi R.
Xia, Kai
Bettella, Francesco
Borglum, Anders D.
Bulik-Sullivan, Brendan K.
Cormican, Paul
Craddock, Nick
de Leeuw, Christiaan
Durmishi, Naser
Gill, Michael
Golimbet, Vera
Hamshere, Marian L.
Holmans, Peter
Hougaard, David M.
Kendler, Kenneth S.
Lin, Kuang
Morris, Derek W.
Mors, Ole
Mortensen, Preben B.
Neale, Benjamin M.
O'Neill, Francis A.
Owen, Michael J.
Milovancevic, Milica Pejovic
Posthuma, Danielle
Powell, John
Richards, Alexander L.
Riley, Brien P.
Ruderfer, Douglas
Rujescu, Dan
Sigurdsson, Engilbert
Silagadze, Teimuraz
Smit, August B.
Stefansson, Hreinn
Steinberg, Stacy
[J]. NATURE GENETICS, 2013, 45 (10) : 1150 - +
[10] Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Li, Zhiqiang
Chen, Jianhua
Yu, Hao
He, Lin
Xu, Yifeng
Zhang, Dai
Yi, Qizhong
Li, Changgui
Li, Xingwang
Shen, Jiawei
Song, Zhijian
Ji, Weidong
Wang, Meng
Zhou, Juan
Chen, Boyu
Liu, Yahui
Wang, Jiqiang
Wang, Peng
Yang, Ping
Wang, Qingzhong
Feng, Guoyin
Liu, Benxiu
Sun, Wensheng
Li, Baojie
He, Guang
Li, Weidong
Wan, Chunling
Xu, Qi
Li, Wenjin
Wen, Zujia
Liu, Ke
Huang, Fang
Ji, Jue
Ripke, Stephan
Yue, Weihua
Sullivan, Patrick F.
O'Donovan, Michael C.
Shi, Yongyong
[J]. NATURE GENETICS, 2017, 49 (11) : 1576 - +

← 1 2 3 4 5 →