Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

被引:0
|
作者
Gautam Sethi
Snehajyoti Chatterjee
Peramaiyan Rajendran
Feng Li
Muthu K Shanmugam
Kwong Fai Wong
Alan Prem Kumar
Parijat Senapati
Amit K Behera
Kam Man Hui
Jeelan Basha
Nagashayana Natesh
John M Luk
Tapas K Kundu
机构
[1] National University of Singapore,Department of Pharmacology, Yong Loo Lin School of Medicine
[2] National University of Singapore,Cancer Science Institute of Singapore
[3] Transcription and Disease Laboratory,Jawaharlal Nehru Centre for Advanced Scientific Research, Molecular Biology and Genetics Unit
[4] Curtin University,School of Biomedical Sciences, Faculty of Health Sciences
[5] University of North Texas,Department of Biological Sciences
[6] National Cancer Centre,Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research
[7] Institute of Molecular and Cell Biology,undefined
[8] Central Government Health Scheme Dispensary,undefined
来源
关键词
HCC; STAT3; Acetylation; Garcinol; Apoptosis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo
    Uehara, Yoshihiko
    Inoue, Masahiro
    Fukuda, Koji
    Yamakoshi, Hiroyuki
    Hosoi, Yoshio
    Kanda, Hiroaki
    Oshima, Masanobu
    Iwabuchi, Yoshiharu
    Shibata, Hiroyuki
    GASTRIC CANCER, 2015, 18 (04) : 774 - 783
  • [22] Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo
    Yoshihiko Uehara
    Masahiro Inoue
    Koji Fukuda
    Hiroyuki Yamakoshi
    Yoshio Hosoi
    Hiroaki Kanda
    Masanobu Oshima
    Yoshiharu Iwabuchi
    Hiroyuki Shibata
    Gastric Cancer, 2015, 18 : 774 - 783
  • [23] Mitochondrial Plasticity Promotes Resistance to Sorafenib and Vulnerability to STAT3 Inhibition in Human Hepatocellular Carcinoma
    Pandit, Shusil K.
    Sandrini, Giada
    Merulla, Jessica
    Nobili, Valentina
    Wang, Xin
    Zangari, Alessia
    Rinaldi, Andrea
    Shinde, Dheeraj
    Carbone, Giuseppina M.
    Catapano, Carlo V.
    CANCERS, 2021, 13 (23)
  • [24] Inhibition of cyclooxygenase-2 suppresses the growth of human hepatocellular carcinoma implants in vivo.
    Kern, MA
    Schöneweiss, MM
    Sahi, D
    Bahlo, M
    Haugg, AM
    Dienes, HP
    Käferstein, H
    Breuhahn, K
    Schirmacher, P
    HEPATOLOGY, 2003, 38 (04) : 405A - 405A
  • [25] Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    Yuan, ZL
    Guan, YJ
    Chatterjee, D
    Chin, YE
    SCIENCE, 2005, 307 (5707) : 269 - 273
  • [26] Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
    Ahmad, Aamir
    Sarkar, Sanila H.
    Aboukameel, Amro
    Ali, Shadan
    Biersack, Bernhard
    Seibt, Sebastian
    Li, Yiwei
    Bao, Bin
    Kong, Dejuan
    Banerjee, Sanjeev
    Schobert, Rainer
    Padhye, Subhash B.
    Sarkar, Fazlul H.
    CARCINOGENESIS, 2012, 33 (12) : 2450 - 2456
  • [27] STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo
    Spitzner, Melanie
    Roesler, Birte
    Bielfeld, Christian
    Emons, Georg
    Gaedcke, Jochen
    Wolff, Hendrik A.
    Rave-Fraenk, Margret
    Kramer, Frank
    Beissbarth, Tim
    Kitz, Julia
    Wienands, Juergen
    Ghadimi, B. Michael
    Ebner, Reinhard
    Ried, Thomas
    Grade, Marian
    INTERNATIONAL JOURNAL OF CANCER, 2014, 134 (04) : 997 - 1007
  • [28] Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
    Gu, Fang-Ming
    Li, Quan-Lin
    Gao, Qiang
    Jiang, Jia-Hao
    Huang, Xiao-Yong
    Pan, Jin-Feng
    Fan, Jia
    Zhou, Jian
    WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (34) : 3922 - 3932
  • [29] Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
    Fang-Ming Gu
    Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis
    Zhou J and Gao Q contributed to the conception and design of the study
    Gu FM
    Jiang JH
    all authors read and approved the f inal manuscript.
    World Journal of Gastroenterology, 2011, 17 (34) : 3922 - 3932
  • [30] Cinobufagin suppresses colorectal cancer growth via STAT3 pathway inhibition
    Bai, Ying
    Wang, Xuye
    Cai, Mengsi
    Ma, Chunbo
    Xiang, Youqun
    Hu, Wanle
    Zhou, Bin
    Zhao, Chengguang
    Dai, Xuanxuan
    Li, Xiaokun
    Zhao, Haiyang
    AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (01): : 200 - +