The Strategies and Challenges of CCR5 Gene Editing in Hematopoietic Stem and Progenitor Cells for the Treatment of HIV

被引:0
|
作者
Karthik V Karuppusamy
Prathibha Babu
Saravanabhavan Thangavel
机构
[1] Christian Medical College,Centre for Stem Cell Research (A unit of inStem, Bengaluru)
[2] Manipal Academy of Higher Education,undefined
来源
关键词
Hematopoietic stem cells; CCR5; Gene editing; HIV gene therapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1607 / 1618
页数:11
相关论文
共 50 条
  • [21] Targeting CCR5: A central approach to HIV treatment and cure strategies
    Yukselten, Yunus
    Wishah, Hanan
    Li, Jessica A.
    Sutton, Richard E.
    VIROLOGY, 2025, 603
  • [22] Clearing the HIV reservoir by transplanting CCR5 deficient stem cells
    Gero Hütter
    Retrovirology, 8 (Suppl 2)
  • [23] CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo
    Xu, Lei
    Yang, Huan
    Gao, Yang
    Chen, Zeyu
    Xie, Liangfu
    Liu, Yulin
    Liu, Ying
    Wang, Xiaobao
    Li, Hanwei
    Lai, Weifeng
    He, Yuan
    Yao, Anzhi
    Ma, Liying
    Shao, Yiming
    Zhang, Bin
    Wang, Chengyan
    Chen, Hu
    Deng, Hongkui
    MOLECULAR THERAPY, 2017, 25 (08) : 1782 - 1789
  • [24] Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles
    Yu, Kyung-Rok
    Natanson, Hannah
    Dunbar, Cynthia E.
    HUMAN GENE THERAPY, 2016, 27 (10) : 729 - 740
  • [25] Pre-Clinical Development and Qualification of ZFN-Mediated Disruption of CCR5 in Human Hematopoietic Stem and Progenitor Cells
    Stan, Rodica
    DiGiusto, David
    Cannon, Paula
    Exline, Colin
    Li, Lijing
    Rao, Anitha
    Wang, Jianbin
    Lee, Gary
    Gregory, Philip D.
    Gonzalez, Nancy
    Bedell, Victoria
    Holmes, Michael C.
    Zaia, John A.
    MOLECULAR THERAPY, 2016, 24 : S289 - S290
  • [26] Designer Nucleases: Gene-Editing Therapies using CCR5 as an Emerging Target in HIV
    Almeida, Maria Joao
    Matos, Ana
    CURRENT HIV RESEARCH, 2019, 17 (05) : 306 - 323
  • [27] Adopting autologous hematopoietic stem cells with non-functional CCR5 and CXCR4 against HIV
    Y Lai
    Bone Marrow Transplantation, 2010, 45 : 770 - 771
  • [28] Adopting autologous hematopoietic stem cells with non-functional CCR5 and CXCR4 against HIV
    Lai, Y.
    BONE MARROW TRANSPLANTATION, 2010, 45 (04) : 770 - 771
  • [29] Why CCR5 is Chosen as the Target for Stem Cell Gene Therapy for HIV Infection?
    Zhang, Jia
    Li, Alice Saint Sinoasia
    Kou, Xiaojin
    Xiao, Li
    Li, Ping
    He, Nongyue
    Li, Kai
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2012, 12 (03) : 2045 - 2048
  • [30] Culture-free gene editing of hematopoietic stem and progenitor cells for the gene therapy of β-hemoglobinopathies
    Venkatesan, V.
    Babu, P.
    Azhagiri, M. K. K.
    Thangavel, S.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A295 - A295