Preclinical Alzheimer disease—the challenges ahead

被引：0
|
作者：
Reisa A. Sperling
Jason Karlawish
Keith A. Johnson
机构：
[1] Center for Alzheimer Research and Treatment,Departments of Neurology
[2] Brigham and Women's Hospital and Massachusetts General Hospital,Departments of Medicine and Medical Ethics and Health Policy
[3] University of Pennsylvania,Departments of Radiology and Neurology
[4] Massachusetts General Hospital,undefined
来源：
Nature Reviews Neurology | 2013年 / 9卷
关键词：
D O I：
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中图分类号：
学科分类号：
摘要：
Pathological changes underlying Alzheimer disease (AD) begin more than 10 years before clinical presentation, and the need for early therapeutic intervention is becoming increasingly recognized. Reisa Sperling and colleagues consider challenges to such an approach—including the difficulty of defining preclinical AD, and ethical issues associated with disclosing information on AD biomarker status to healthy individuals—and discuss possible ways to overcome these hurdles.
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页码：54 / 58
页数：4
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