Synthesis and Antitumor Properties of New 1,2,4-Triazoles and 1,3,4-Thiadiazoles

被引：0
|
作者：
T. R. Ovsepyan
F. G. Arsenyan
L. E. Nersesyan
I. S. Danielyan
A. G. Agaronyan
R. G. Melik-Ogandzhanyan
机构：
[1] National Academy of Sciences of the Republic of Armenia,A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry
来源：
Pharmaceutical Chemistry Journal | 2017年 / 50卷
关键词：
triazole; thiadiazole; alkylation; aminomethylation; experimental tumors; tumor DNA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New S-substituted derivatives were synthesized via alkylation of mercapto-substituted 1,2,4-triazoles and 1,3,4-thiadiazoles by various aliphatic and aromatic halides. Aminomethylation of 5-thio-1,2,4-triazoles formed the corresponding Mannich bases. The antitumor properties of the synthesized compounds against sarcoma 37 and EAC grafted tumor models and their influence on DNA methylation were studied
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页码：724 / 727
页数：3
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