Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

被引：0
|
作者：
Erkan Karakas
Noriko Simorowski
Hiro Furukawa
机构：
[1] Cold Spring Harbor Laboratory,
[2] WM Keck Structural Biology Laboratory,undefined
来源：
Nature | 2011年 / 475卷
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摘要：
Ifenprodil, a phenylethanolamine first developed as an adrenergic antagonist and now widely used as an antihypertensive, also has a neuroprotective effect through receptors. A study of this interaction shows that the NMDA receptor subunits GluN1 and GluN2B form heterodimers that bind ifenprodil at the GluN1/GluN2B interface. Conformational mobility in the GluN2B amino-terminal domain is essential for ifenprodil-mediated inhibition of the NMDA receptors. These findings may be relevant to the design of therapeutics to target specific NMDA receptor subtypes for use in neurological disorders.
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页码：249 / 253
页数：4
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