Radioimmunotherapy of B-cell non-Hodgkin's lymphoma

被引：0
|
作者：
Ernst J. Postema
Otto C. Boerman
Wim J. Oyen
John M. Raemaekers
Frans H. Corstens
机构：
[1] Department of Nuclear Medicine,
[2] University Medical Center Nijmegen,undefined
[3] PO Box 9101,undefined
[4] 6500 HB Nijmegen,undefined
[5] Department of Hematology,undefined
[6] University Medical Center Nijmegen,undefined
来源：
European Journal of Nuclear Medicine | 2001年 / 28卷
关键词：
Non-Hodgkin's lymphoma Radioimmunotherapy Monoclonal antibodies Review Classification of non-Hodgkin's lymphoma;
D O I：
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中图分类号：
学科分类号：
摘要：
In the past decade, several new antibody-based therapies – using either radiolabelled or unlabelled monoclonal antibodies – have become available for the treatment of patients with refractory or recurrent non-Hodgkin's lymphoma (NHL). Unlabelled monoclonal antibodies (mAbs) kill lymphoma cells by activating host immune effector mechanisms, or by inducing apoptosis. These mAbs can also be used to guide radionuclides to the lymphoma. This radioimmunotherapy (RIT) has been studied with various nuclides (131I, 90Y, 67Cu and 186Re) and with various mAbs. In this review the radionuclides, methods of dosing and recent RIT studies in patients with B-cell NHL are reviewed. Most of these studies demonstrate that RIT is an effective new treatment modality for NHL.
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页码：1725 / 1735
页数：10
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