Radioimmunotherapy of B-cell non-Hodgkin's lymphoma

被引：39
|
作者：
Postema, EJ
Boerman, OC
Oyen, WJG
Raemaekers, JMM
Corstens, FHM
机构：
[1] Univ Nijmegen, Med Ctr, Dept Nucl Med, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen, Med Ctr, Dept Hematol, Nijmegen, Netherlands
来源：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 2001年 / 28卷 / 11期
关键词：
non-Hodgkin's lymphoma; radioimmunotherapy; monoclonal antibodies; review; classification of non-Hodgkin's lymphoma;
D O I：
10.1007/s002590100570
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
In the past decade, several new antibody-based therapies - using either radiolabelled or unlabelled monoclonal antibodies - have become available for the treatment of patients with refractory or recurrent non-Hodgkin's lymphoma (NHL). Unlabelled monoclonal antibodies (mAbs) kill lymphoma cells by activating host immune effector mechanisms., or by inducing apoptosis. These mAbs can also be used to guide radionuclides to the lymphoma. This radioimmunotherapy (RIT) has been studied with various nuclides (I-131, Y-90, Cu-67 and Re-186) and with various mAbs. In this review the radionuclides, methods of dosing and recent RIT studies in patients with B-cell NHL are reviewed. Most of these studies demonstrate that RIT is an effective new treatment modality for NHL.
引用
收藏
页码：1725 / 1735
页数：11
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