Exponential Spread of Hepatitis C Virus Genotype 4a in Egypt

被引:0
|
作者
Yasuhito Tanaka
Salah Agha
Niveen Saudy
Fuat Kurbanov
Etsuro Orito
Takanobu Kato
Mostafa Abo-Zeid
Mohamed Khalaf
Yuzo Miyakawa
Masashi Mizokami
机构
[1] Nagoya City University Graduate School of Medical Science,Department of Clinical Molecular Informative Medicine
[2] Kawasumi,Department of Internal Medicine and Molecular Science
[3] Mizuho,Department of Clinical Pathology
[4] Nagoya 467-8601,Department of Surgery
[5] Nagoya City University Graduate School of Medical Sciences,Department of Clinical Pathology
[6] Nagoya,undefined
[7] Faculty of Medicine,undefined
[8] Mansoura University,undefined
[9] Mansoura,undefined
[10] Faculty of Medicine,undefined
[11] Mansoura University,undefined
[12] Mansoura,undefined
[13] Faculty of Medicine,undefined
[14] Assuit University,undefined
[15] Assuit,undefined
[16] Miyakawa Memorial Research Foundation,undefined
[17] Tokyo,undefined
来源
Journal of Molecular Evolution | 2004年 / 58卷
关键词
Hepatic C virus; Genotype 4a; Egypt; Neutral theory; Molecular evolutionary analyses; Schistosomiasis; Parenteral treatment;
D O I
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学科分类号
摘要
Hepatitis C virus (HCV) infects >10% of the general population in Egypt, in which intravenous injection with an antimony compound for endemic schistosomiasis in the past has been implicated. To simulate the epidemic history of HCV in Egypt, sera were obtained from 3608 blood donors at 13 governorates in or surrounding the Nile valley during 1999. The prevalence of antibody to HCV (anti-HCV) and genotypes was determined in them, and the molecular evolutionary analysis based on the neutral theory was applied to HCV isolates of genotype 4a, which is outstandingly prevalent in Egypt and indigenous there. Of 3608 sera, 317 (8.8%) were positive for anti-HCV. The molecular evolutionary analysis on 47 HCV genotype 4a isolates of carriers from various districts in Egypt indicated that the spread of HCV-4a would have increased exponentially during the 1940s through 1980 when oral medications became available. In conclusion, the estimated spread time is consistent with the duration of intravenous antimony campaigns in Egypt.
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页码:191 / 195
页数:4
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