Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

被引:0
|
作者
Chen Qiao
Qian Zhang
Qingling Jiang
Ting Zhang
Miaomiao Chen
Yi Fan
Jianhua Ding
Ming Lu
Gang Hu
机构
[1] Nanjing Medical University,Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology
[2] Nanjing University of Chinese Medicine,Department of Pharmacology
[3] Nanjing Medical University,Neuroprotective Drug Discovery Key Laboratory, Department of Pharmacology
[4] Affiliated Hospital of Jiangsu University,Department of Clinical Pharmacy
[5] Jiangsu University,undefined
关键词
NLRP3 inflammasome; Systemic inflammation; Neurodegeneration; IL-1β; Parkinson’s disease;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson's disease
    Zhao, Yong-fei
    Zhang, Qiong
    Xi, Jian-ying
    Li, Yan-hua
    Ma, Cun-gen
    Xiao, Bao-guo
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 353 (1-2) : 28 - 37
  • [32] SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease
    Wang, WY
    Shi, LY
    Xie, YB
    Ma, C
    Li, WM
    Su, XW
    Huang, SJ
    Chen, RH
    Zhu, ZY
    Mao, ZX
    Han, YF
    Li, MT
    NEUROSCIENCE RESEARCH, 2004, 48 (02) : 195 - 202
  • [33] Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway
    Gottschalk, Carl G.
    Jana, Malabendu
    Roy, Avik
    Patel, Dhruv R.
    Pahan, Kalipada
    JOURNAL OF NEUROSCIENCE, 2021, 41 (10): : 2287 - 2300
  • [34] Cinnamic acid protects the nigrostriatum in MPTP mouse model of Parkinson's disease via the PPARα
    Prorok, Tim
    Pahan, Kalipada
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2018, 13 : S68 - S69
  • [35] Modulation of Intestinal Inflammation and Protection of Dopaminergic Neurons in Parkinson's Disease Mice through a Probiotic Formulation Targeting NLRP3 Inflammasome
    Zhou, Liping
    Wong, Ka Ying
    Xie, Hongxiang
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2025, 20 (01)
  • [36] Cinnamic acid protects the nigrostriatum in MPTP mouse model of Parkinson's disease via the PPARα
    Prorok, Tim
    Pahan, Kalipada
    JOURNAL OF NEUROVIROLOGY, 2018, 24 : S68 - S69
  • [37] MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model
    Sun, Qiang
    Wang, Songlin
    Chen, Jun
    Cai, Hongxia
    Huang, Wei
    Zhang, Yueliang
    Wang, Lei
    Xing, Yu
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (12) : 23379 - 23387
  • [38] Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson’s Disease
    Nidheesh Thadathil
    Jianfeng Xiao
    Roderick Hori
    Stephen E. Alway
    Mohammad Moshahid Khan
    Journal of Neuroimmune Pharmacology, 2021, 16 : 667 - 678
  • [39] Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson's Disease
    Thadathil, Nidheesh
    Xiao, Jianfeng
    Hori, Roderick
    Alway, Stephen E.
    Khan, Mohammad Moshahid
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2021, 16 (03) : 667 - 678
  • [40] Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease
    Dai, Yu-bing
    Tan, Xin-jie
    Wu, Wan-fu
    Warner, Margaret
    Gustafsson, Jan-Ake
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (32) : 13112 - 13117