Flow-Injection Chemiluminescence Determination of Enalapril Maleate in Pharmaceuticals and Biological Fluids Using Tris(2,2′-bipyridyl)ruthenium(II)

被引：0
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作者：
Nawal A. A. Alarfaj
机构：
[1] Women Student-Medical Studies and Sciences Sections,Chemistry Department, College of Science
[2] King Saud University,undefined
来源：
Analytical Sciences | 2003年 / 19卷
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摘要：
A chemiluminescence (CL) method using flow injection (FI) has been investigated for the rapid and sensitive determination of enalapril maleate. The method is based on the CL reaction of the drug with tris(2,2′-bipyridyl)ruthenium(II), Ru(bipy)32+ and acidic potassium permanganate. After selecting the best operating parameters, calibration graphs were obtained over concentration ranges of 0.005–0.2 µg/ml and 0.7–100 µg/ml with a detection limit (S/N = 2) of 1.0 ng/ml. The average % found was 99.9 ± 0.7 and 100.2 ± 0.3 for the two concentration ranges respectively. %RSD (n = 10) for 5.0 µg/ml was 0.44. The method was successfully applied to the determination of enalapril maleate in dosage forms and biological fluids without interferences.
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页码：1145 / 1150
页数：5
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