FPR2 promotes invasion and metastasis of gastric cancer cells and predicts the prognosis of patients

被引:0
|
作者
Xi-Lu Hou
Cheng-Dong Ji
Jun Tang
Yan-Xia Wang
Dong-Fang Xiang
Hai-Qing Li
Wei-Wei Liu
Jiao-Xue Wang
He-Zhong Yan
Yan Wang
Peng Zhang
You-Hong Cui
Ji-Ming Wang
Xiu-Wu Bian
Wei Liu
机构
[1] The 105th Hospital of People’s Liberation Army,Department of Gastroenterology
[2] Third Military Medical University,Institute of Pathology & Southwest Cancer Center, and Key Laboratory of Tumor Immunopathology, Ministry of Education of China
[3] National Cancer Institute,Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Formyl peptide receptor 2 (FPR2), a classical chemoattractant receptor of G-protein-coupled receptors, is reported to be involved in invasion and metastasis of some cancers, but the role of FPR2 in gastric cancer (GC) has not yet been elucidated. In this study, we found that the levels of FPR2 expression in GC were positively correlated with invasion depth, lymph node metastasis and negatively correlated with the patients’ overall survival. Multivariate analysis indicated that FPR2 expression was an independent prognostic marker for GC patients. FPR2-knockdown significantly abrogated the migration and invasion stimulated by Hp(2–20) and Ac(2–26), two well-characterized ligands for FPR2 in GC cells. FPR2 deletion also reduced the tumorigenic and metastatic capabilities of GC cells in vivo. Mechanistically, stimulation with FPR2 ligands resulted in down-regulation of E-cadherin and up-regulation of vimentin, which were reversed by FPR2 knock-down, implying the involvement of epithelial–mesenchymal transition (EMT). Moreover, the activation of FPR2 was accompanied with ERK1/2 phosphorylation, which could be attenuated by FPR2 silencing or treatment with MEK inhibitor, PD98059. Altogether, our results demonstrate that FPR2 is functionally involved in invasion and metastasis, and potentially acts as a novel prognostic marker as well as a potential therapeutic target in human GC.
引用
收藏
相关论文
共 50 条
  • [1] FPR2 promotes invasion and metastasis of gastric cancer cells and predicts the prognosis of patients
    Hou, Xi-Lu
    Ji, Cheng-Dong
    Tang, Jun
    Wang, Yan-Xia
    Xiang, Dong-Fang
    Li, Hai-Qing
    Liu, Wei-Wei
    Wang, Jiao-Xue
    Yan, He-Zhong
    Wang, Yan
    Zhang, Peng
    Cui, You-Hong
    Wang, Ji-Ming
    Bian, Xiu-Wu
    Liu, Wei
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [2] Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients
    Liu, Jia-jia
    Liu, Jun-yan
    Chen, Jun
    Wu, Yi-xi
    Yan, Peng
    Ji, Cheng-dong
    Wang, Yan-xia
    Xiang, Dong-fang
    Zhang, Xia
    Zhang, Peng
    Cui, You-hong
    Wang, Ji Ming
    Bian, Xiu-wu
    Qian, Feng
    [J]. CANCER LETTERS, 2016, 376 (01) : 110 - 117
  • [3] TRAF6 promotes the invasion and metastasis and predicts a poor prognosis in gastric cancer
    Han, Fei
    Zhang, Long
    Qiu, Weizhe
    Yi, Xianghua
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2016, 212 (01) : 31 - 37
  • [4] LTBP2 promotes the migration and invasion of gastric cancer cells and predicts poor outcome of patients with gastric cancer
    Wang, Jun
    Liang, Wen-Jia
    Min, Guang-Tao
    Wang, Hong-Peng
    Chen, Wei
    Yao, Nan
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 52 (06) : 1886 - 1898
  • [5] High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells
    Zhang, Yu
    Gu, Xinliang
    Zhu, Feilong
    Li, Yang
    Huang, Yuejiao
    Ju, Shaoqing
    [J]. SCIENTIFIC REPORTS, 2023, 13 (01)
  • [6] High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells
    Yu Zhang
    Xinliang Gu
    Feilong Zhu
    Yang Li
    Yuejiao Huang
    Shaoqing Ju
    [J]. Scientific Reports, 13
  • [7] TNFAIP6 promotes invasion and metastasis of gastric cancer and indicates poor prognosis of patients
    Zhang, Xiangwen
    Xue, Jiaming
    Yang, Huiliang
    Zhou, Tingting
    Zu, Guo
    [J]. TISSUE & CELL, 2021, 68
  • [8] Upregulation of miR-552 Predicts Unfavorable Prognosis of Gastric Cancer and Promotes the Proliferation, Migration, and Invasion of Gastric Cancer Cells
    Feng, Xiaobo
    Zhu, Mei
    Liao, Bingling
    Tian, Tianning
    Li, Minhong
    Wang, Zhibo
    Chen, Guoyan
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 (03) : 103 - 110
  • [9] COX-2 promotes metastasis and predicts prognosis in gastric cancer via regulating mTOR
    Xiang, Liangliang
    Wang, Weimin
    Zhou, Zhen
    Lv, Mengying
    Tao, Li
    Ni, Tengyang
    Deng, Jianliang
    Masatara, Sunagawa
    Liu, Yanqing
    Zhou, Yan
    [J]. BIOMARKERS IN MEDICINE, 2020, 14 (06) : 421 - 432
  • [10] Microvessel count predicts metastasis and prognosis in patients with gastric cancer
    Araya, M
    Terashima, M
    Takagane, A
    Abe, K
    Nishizuka, S
    Yonezawa, H
    Irinoda, T
    Nakaya, T
    Saito, K
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 1997, 65 (04) : 232 - 236