Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients

被引:45
|
作者
Liu, Jia-jia [1 ,2 ]
Liu, Jun-yan [1 ,2 ]
Chen, Jun [1 ,2 ]
Wu, Yi-xi [1 ,2 ]
Yan, Peng [1 ,2 ]
Ji, Cheng-dong [3 ,4 ]
Wang, Yan-xia [3 ,4 ]
Xiang, Dong-fang [3 ,4 ]
Zhang, Xia [3 ,4 ]
Zhang, Peng [3 ,4 ]
Cui, You-hong [3 ,4 ]
Wang, Ji Ming [3 ,4 ,5 ]
Bian, Xiu-wu [3 ,4 ]
Qian, Feng [1 ,2 ]
机构
[1] Third Mil Med Univ, Southwest Hosp, Dept Gen Surg, Chongqing 400038, Peoples R China
[2] Third Mil Med Univ, Southwest Hosp, Ctr Minimal Invas Gastrointestinal Surg, Chongqing 400038, Peoples R China
[3] Third Mil Med Univ, Southwest Hosp, Inst Pathol, Key Lab Tumor Immunopathol,Minist Educ China, Chongqing 400038, Peoples R China
[4] Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, Key Lab Tumor Immunopathol,Minist Educ China, Chongqing 400038, Peoples R China
[5] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA
基金
美国国家科学基金会;
关键词
Scinderin; Gastric cancer; Invasion; Metastasis; Filopodia; Cdc42; EPITHELIAL-MESENCHYMAL TRANSITION; MOLECULAR ARCHITECTURE; INHIBITS PROLIFERATION; ACTIN; DIFFERENTIATION; MOTILITY; FILOPODIA; MIGRATION; ADSEVERIN; LAMELLIPODIA;
D O I
10.1016/j.canlet.2016.03.035
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Invasion and metastasis are major malignant characteristics of human gastric cancer (GC), but the underlying molecular mechanisms are poorly understood. Recent studies have shown that scinderin (SCIN), an actin severing and capping protein that regulates the actin cytoskeleton, is involved in the proliferation and migration of certain cancer cells. Accordingly, this study aimed to investigate the potential role of SCIN in the invasion and metastasis of human GC cells and to evaluate its prognostic value for GC patients. We found that high levels of SCIN expression in GC tumors were correlated with poor overall survival of patients. Silencing of SCIN effectively suppressed the migratory and invasive capabilities of human GC cells in vitro and tumorigenicity and metastasis in vivo. Furthermore, knockdown of SCIN markedly inhibited the formation of filopodia, decreasing GC cell migration and the expression of Cdc42, an important regulator of filopodia by GC cells. These findings suggest that SCIN may be a novel prognostic marker and a potential therapeutic target in human GC. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:110 / 117
页数:8
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