Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

被引：0

作者：

Michael A. Durante

Stefan Kurtenbach

Zoukaa B. Sargi

J. William Harbour

Rhea Choi

Sarah Kurtenbach

Garrett M. Goss

Hiroaki Matsunami

Bradley J. Goldstein

机构：

[1] University of Miami Miller School of Medicine,Medical Scientist Training Program

[2] University of Miami Miller School of Medicine,Interdisciplinary Stem Cell Institute

[3] University of Miami Miller School of Medicine,Bascom Palmer Eye Institute

[4] University of Miami Miller School of Medicine,Sylvester Comprehensive Cancer Center

[5] University of Miami Miller School of Medicine,Department of Otolaryngology

[6] University of Miami Miller School of Medicine,Graduate Program in Neuroscience

[7] Duke Institute for Brain Sciences,Department of Molecular Genetics and Microbiology

[8] Duke University Medical Center,Department of Neurobiology

[9] Duke Institute for Brain Sciences,Department of Head and Neck Surgery & Communication Sciences

[10] Duke University Medical Center,undefined

[11] Duke University Medical Center,undefined

来源：

Nature Neuroscience | 2020年 / 23卷

关键词：

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摘要：

The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.

引用

页码：323 / 326

页数：3

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