Theoretically substantiated expressions are suggested for estimating the tray efficiency in distillation with nonequimolar mass transfer. Binary interaction parameters are presented for the UNIQUAC calculation of the vapor-liquid equilibrium in the six-component system consisting of water, methanol, ammonia, monomethylamine, dimethylamine, and trimethylamine. An approach to simulating the operation of tray columns with nonequimolar mass transfer is proposed.