Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota

被引:0
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作者
Tong Zhao
Yue Zhang
Linhua Nan
Qing Zhu
Shukai Wang
Yutao Xie
Xinling Dong
Cui Cao
Xiaoliang Lin
Yu Lu
Yuxia Liu
Linjuan Huang
Guiping Gong
Zhongfu Wang
机构
[1] Northwest University,Shaanxi Natural Carbohydrate Resource Engineering Research Center, College of Food Science and Technology
[2] Infinitus (China) Company Ltd,undefined
来源
npj Biofilms and Microbiomes | / 9卷
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摘要
Understanding how dietary polysaccharides affect mucin O-glycosylation and gut microbiota could provide various nutrition-based treatments. Here, the O-glycan profile of the colonic mucosa and gut microbiome were investigated in C57BL/6J mice fed six structurally diverse dietary polysaccharides and a mixture of six fibers. Dietary polysaccharides increased total O-glycans, mainly by stimulating neutral glycans. Highly branched arabinogalactan promoted terminally fucosylated core 1 O-glycans; whereas linear polysaccharides, including pectin, konjac glucomannan, inulin, and the fiber mixture, favored terminally di-fucosylated O-glycans. The last three polysaccharides also lowered the level of sulfated O-glycans and sialylated mono-fucosylated O-glycans. Varied monosaccharide composition in mixed polysaccharides had a synergistic beneficial effect, boosting fucosylated neutral glycans, decreasing acidic glycans, and stimulating microbial richness and diversity. Dietary polysaccharides containing arabinose and sulfate groups enhanced the relative abundances of Akkermansia and Muribaculaceae, respectively. The present comparison reveals the relationship between dietary polysaccharide structure, mucin O-glycan composition, and intestinal microorganisms.
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