Synthesis of some new 2,6-disubstituted-3(2H)-pyridazinone derivatives and investigation of their analgesic, anti-inflammatory and antimicrobial activities

被引：0
|
作者：
Didem Tiryaki
Murat Sukuroglu
Deniz S. Dogruer
Esra Akkol
Selda Ozgen
M. Fethi Sahin
机构：
[1] Gazi University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[2] Gazi University,Department of Pharmacognosy, Faculty of Pharmacy
[3] Gazi University,Department of Microbiology, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
3(2; )-pyridazinone; Analgesic activity; Anti-inflammatory activity; Antimicrobial activity;
D O I：
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中图分类号：
学科分类号：
摘要：
In this study, 12 new 3(2H)-pyridazinone derivatives carrying 4-substituted phenylpiperazinylethyl moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 9c showed the best analgesic and anti-inflammatory activities without causing any gastric effect in stomachs of tested animals. In addition, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.
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页码：2553 / 2560
页数：7
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