Solution-phase reductive cyclization of 2-quinoxalinol analogs: Systematic study of parallel synthesis

被引：0
|
作者：
Xiang-Hong Wu
Gang Liu
Jing Zhang
Zhan-Guo Wang
Song Xu
Suo-De Zhang
Liang Zhang
Lin Wang
机构：
[1] Chinese Academy of Medical Sciences & Peking Union Medical College,Institute of Materia Medica
来源：
Molecular Diversity | 2004年 / 8卷
关键词：
aromatic nitro reduction; -dinitro benzene; parallel synthesis; 2-quinoxalinol analog; reductive cyclization; solution-phase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.
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页码：165 / 174
页数：9
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