Protein degradation during aging: The lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems

被引：0

作者：

Niki Chondrogianni

Emmanouil G. Fragoulis

Efstathios S. Gonos

机构：

[1] Institute of Biological Research and Biotechnology,National Hellenic Research Foundation

[2] University of Athens,Department of Biochemistry & Molecular Biology, Panepistemiopolis

[3] School of Biological Sciences,undefined

来源：

Biogerontology | 2002年 / 3卷

关键词：

aging; calpains; lysosomes; proteasome; protein oxidation; proteolysis; senescence;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the increased failure of homeostasis during aging is due to the impaired function of the major cellular proteolytic mechanisms mediated by the lysosome, the calpains and the proteasome. This article will address the issue of the function of these cellular proteolytic systems during aging.

引用

页码：121 / 123

页数：2

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