WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity

被引:0
|
作者
Xuhui Yan
Feiqing Liu
Junjun Yan
Mengjun Hou
Min Sun
Delin Zhang
Zhou Gong
Xu Dong
Chun Tang
Ping Yin
机构
[1] Huazhong Agricultural University,National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory
[2] Chinese Academy of Sciences,Innovation Academy for Precision Measurement Science and Technology
[3] Peking University,College of Chemistry and Molecular Engineering, and Peking
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Functional Characterization of Two RNA Methyltransferase Genes METTL3 and METTL14 Uncovers the Roles of m6A in Mediating Adaptation of Plutella xylostella to Host Plants
    Wang, Bei-Bei
    Lai, Ying-Fang
    Li, Fei-Fei
    Jiao, Lu
    Qiao, Qing-Xuan
    Li, Shan-Yu
    Xiang, Xiu-Juan
    Liao, Huang
    You, Min-Sheng
    He, Wei-Yi
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (17)
  • [32] METTL14 upregulates TCF1 through m6A mRNA methylation to stimulate osteogenic activity in osteoporosis
    Wang, Xuepeng
    Zou, Chunchun
    Li, Maoqiang
    Hou, Changju
    Jiang, Wu
    Bian, Zhenyu
    Zhu, Liulong
    [J]. HUMAN CELL, 2023, 36 (01) : 178 - 194
  • [33] M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer
    Cai, Changjing
    Long, Jie
    Huang, Qiaoqiao
    Han, Ying
    Peng, Yinghui
    Guo, Cao
    Liu, Shanshan
    Chen, Yihong
    Shen, Edward
    Long, Kexin
    Wang, Xinwen
    Yu, Jian
    Shen, Hong
    Zeng, Shan
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [34] The m6A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia
    Sang, Lina
    Wu, Xia
    Yan, Tianyou
    Naren, Duolan
    Liu, Xiaoyan
    Zheng, Xue
    Zhang, Nanchen
    Wang, Huifang
    Li, Yarong
    Gong, Yuping
    [J]. JOURNAL OF CANCER, 2022, 13 (03): : 1019 - 1030
  • [35] The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells
    Taketo, Kosuke
    Konno, Masamitsu
    Asai, Ayumu
    Koseki, Jun
    Toratani, Masayasu
    Satoh, Taroh
    Doki, Yuichiro
    Mori, Masaki
    Ishii, Hideshi
    Ogawa, Kazuhiko
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 52 (02) : 621 - 629
  • [36] Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury
    Wang, Changsheng
    Zhu, Xitian
    Chen, Rongsheng
    Zhang, Xiaobo
    Lian, Nancheng
    [J]. ENEURO, 2023, 10 (06)
  • [37] Progression of Thyroid Carcinoma Is Promoted by the m6A Methyltransferase METTL3 Through Regulating m6A Methylation on TCF1
    Wang, Kejin
    Jiang, Lin
    Zhang, Yan
    Chen, Chao
    [J]. ONCOTARGETS AND THERAPY, 2020, 13 : 1605 - 1612
  • [38] m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype
    Liu, Pingyu
    Li, Fuming
    Lin, Jianhuang
    Fukumoto, Takeshi
    Nacarelli, Timothy
    Hao, Xue
    Kossenkov, Andrew, V
    Simon, M. Celeste
    Zhang, Rugang
    [J]. NATURE CELL BIOLOGY, 2021, 23 (04) : 355 - U89
  • [39] m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype
    Pingyu Liu
    Fuming Li
    Jianhuang Lin
    Takeshi Fukumoto
    Timothy Nacarelli
    Xue Hao
    Andrew V. Kossenkov
    M. Celeste Simon
    Rugang Zhang
    [J]. Nature Cell Biology, 2021, 23 : 355 - 365
  • [40] RNA methylation-driven assembly of fluorescence-encoded nanostructures for sensitive detection of m6A modification writer METTL3/14 complex in human breast tissues
    Liu, Wen-jing
    Wang, Lu-yao
    Sheng, Zhimei
    Zhang, Baogang
    Zou, Xiaoran
    Zhang, Chun-yang
    [J]. BIOSENSORS & BIOELECTRONICS, 2023, 240