Synthesis and structure of 3-(3-acetoxyalkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanoic acids

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作者
I. V. Ukrainets
O. V. Gorokhova
K. V. Andreeva
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[1] National University of Pharmacy,
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Propanoic Acid; Torsion Angle; AcOH; Colorless Crystal; Cyano Group;
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摘要
Treatment of 1-(2-cyanoethyl)-4-hydroxy-N-(hydroxyalkyl)-2-oxo-1,2-dihydroquinoline-3-carboxamides with a solution of hydrogen chloride in aqueous acetic acid ensures selective transformation of the cyano group into amide or carboxy with simultaneous acetylation of the hydroxyalkyl fragments.
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页码:63 / 65
页数:2
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