SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity

被引：0
|
作者：
Masatoshi Nomura
Hai-Lei Zhu
Lixiang Wang
Hidetaka Morinaga
Ryoichi Takayanagi
Noriyoshi Teramoto
机构：
[1] Kyushu University,Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences
[2] Saga University,Department of Pharmacology, Faculty of Medicine
来源：
Diabetologia | 2014年 / 57卷
关键词：
Insulin; K; channels; Pancreatic beta cells; SMAD2; TGF-β;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：157 / 166
页数：9
相关论文
共 50 条
  • [31] Eugenosedin-A improves obesity-related hyperglycemia by regulating ATP-sensitive K+ channels and insulin secretion in pancreatic β cells
    Lin, Rong-Jyh
    Yen, Yu-Kwan
    Lee, Chien-Hsing
    Hsieh, Su-Ling
    Chang, Yu-Chin
    Juan, Yung-Shun
    Long, Cheng-Yu
    Shen, Kuo-Ping
    Wu, Bin-Nan
    BIOMEDICINE & PHARMACOTHERAPY, 2022, 145
  • [32] CAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets
    Yajima, H
    Komatsu, M
    Schermerhorn, T
    Aizawa, T
    Kaneko, T
    Nagai, M
    Sharp, GWG
    Hashizume, K
    DIABETES, 1999, 48 (05) : 1006 - 1012
  • [33] cAMP-independent decrease of ATP-sensitive K+ channel activity by GLP-1 in rat pancreatic β-cells
    Suga, S
    Kanno, T
    Ogawa, Y
    Takeo, T
    Kamimura, N
    Wakui, M
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2000, 440 (04): : 566 - 572
  • [34] cAMP-independent decrease of ATP-sensitive K+ channel activity by GLP-1 in rat pancreatic β-cells
    Sechiko Suga
    Takahiro Kanno
    Yoshiji Ogawa
    Teruko Takeo
    Noritaka Kamimura
    Makoto Wakui
    Pflügers Archiv, 2000, 440 (4): : 566 - 572
  • [35] Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel
    Lee, Sun-Hee
    Lim, Sung-Won
    Lee, Young-Mi
    Lee, Hoi-Seon
    Kim, Dae-Ki
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012, 29 (05) : 913 - 919
  • [36] Intracellular Ca2+ modulation of ATP-sensitive K+ channel activity in acetylcholine-induced activation of rat pancreatic β-cells
    Nakano, K
    Suga, S
    Takeo, T
    Ogawa, Y
    Suda, T
    Kanno, T
    Wakui, M
    ENDOCRINOLOGY, 2002, 143 (02) : 569 - 576
  • [37] IMPAIRED GLUCOSE SENSITIVITY ON ATP-SENSITIVE K+ CHANNELS OF PANCREATIC BETA-CELLS IN GK RAT, A NOVEL GENETIC NIDDM MODEL
    TSUURA, Y
    ISHIDA, H
    OKADA, Y
    SEINO, Y
    DIABETES, 1993, 42 : A69 - A69
  • [38] Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome: Role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel
    Kawajiri, M
    Okano, Y
    Kuno, M
    Tokuhara, D
    Hase, Y
    Inada, H
    Tashiro, F
    Miyazaki, JI
    Yamano, T
    PEDIATRIC RESEARCH, 2006, 59 (03) : 359 - 364
  • [39] Unregulated Insulin Secretion by Pancreatic Beta Cells in Hyperinsulinism/Hyperammonemia Syndrome: Role of Glutamate Dehydrogenase, ATP-Sensitive Potassium Channel, and Nonselective Cation Channel
    Mie Kawajiri
    Yoshiyuki Okano
    Miyuki Kuno
    Daisuke Tokuhara
    Yutaka Hase
    Hiroshi Inada
    Fumi Tashiro
    Jun-Ichi Miyazaki
    Tsunekazu Yamano
    Pediatric Research, 2006, 59 : 359 - 364
  • [40] IMIDAZOLINE ANTAGONISTS OF ALPHA-2-ADRENOCEPTORS INCREASE INSULIN RELEASE INVITRO BY INHIBITING ATP-SENSITIVE K+ CHANNELS IN PANCREATIC BETA-CELLS
    JONAS, JC
    PLANT, TD
    HENQUIN, JC
    BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (01) : 8 - 14
12345