Aggregator compounds confound amyloid fibrillization assay

被引：0

作者：

Gilbert M Rishton

机构：

[1] Gilbert M. Rishton is director of the Channel Islands Alzheimer's Institute,

[2] CSUCI,undefined

[3] Aliso Hall,undefined

[4] One University Drive,undefined

[5] Camarillo,undefined

[6] California 93012,undefined

[7] USA. gilbert.rishton@csuci.edu,undefined

来源：

Nature Chemical Biology | 2008年 / 4卷

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学科分类号：

摘要：

The highly sensitive and artificial biochemical assays that enable high-throughput screening are vulnerable to artifact-generating compounds that occur in drug screening collections. An investigation of known aggregator compounds and amyloid fibrillization inhibitors suggests that such inhibitors operate via a nonspecific mechanism in a well-used assay of amyloid fibrillization.

引用

页码：159 / 160

页数：1

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