Effect of thapsigargin on inhibitory synaptic transmission between cultured neurons of the rat hippocampus

被引：0
|
作者：
E. P. Mizerna
S. A. Fedulova
N. S. Veselovsky
机构：
[1] National Academy of Sciences of Ukraine,International Center for Molecular Physiology
[2] National Academy of Sciences of Ukraine,Bogomolets Institute of Physiology
来源：
Neurophysiology | 2007年 / 39卷
关键词：
endoplasmic reticulum; thapsigargin; calcium stores; cultured neurons; rat hippocampus;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We carried out electrophysiological experiments on cultured neurons of the rat hippocampus. The voltage-clamp technique and extracellular stimulation of single presynaptic axons were used for measurements of the evoked inhibitory postsynaptic currents (eIPSCs). It was found that 1 µM thapsigargin is capable of modulating inhibitory synaptic transmission, and the effects were ambivalent. Among 21 examined cells, eIPSCs decreased in 15 neurons and were augmented in 6 units; the kinetic parameters of these currents underwent no changes.
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页码：327 / 329
页数：2
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