MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

被引:0
|
作者
Li Xu
Wen J. Sun
Ai J. Jia
Lu L. Qiu
Bing Xiao
Lin Mu
Jian M. Li
Xiu F. Zhang
Yan Wei
Cong Peng
Dong S. Zhang
Xu D. Xiang
机构
[1] The Affiliated Cancer Hospital of Xiangya School of Medicine and Hunan Cancer Hospital,Department of the Second Thoracic Medicine
[2] Central South University,Department of Respiratory Medicine, Hunan Centre for Evidence
[3] The Second Xiangya Hospital,based Medicine, Research Unit of Respiratory Diseases
[4] Central South University,Department of Emergency
[5] The Second Xiangya Hospital,Department of Respiratory Medicine
[6] Central South University,Department of Respiratory Medicine
[7] Peace Hospital,Department of Respiratory Medicine
[8] Changzhi Medical College,Department of Respiratory
[9] Hunan Provincial People’s Hospital,Dermatology and Venereology Department
[10] The Second Hospital,undefined
[11] University of South China,undefined
[12] The First Hospital of Guangyuan City,undefined
[13] Xiangya Hospital,undefined
[14] Central South University,undefined
来源
关键词
Neutrophils-dominant asthma; Hypoxia inducible factor-1α; Methtyl-CpG binding domain protein 2; T helper 17 cells;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Increased HIF-1α expression in T cells and associated with enhanced Th17 pathway in systemic lupus erythematosus
    Liao, Hsiu-Jung
    Chu, Ching-Liang
    Wang, Szu-Chieh
    Lee, Hua-Yi
    Wu, Chien-Sheng
    JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2022, 121 (12) : 2446 - 2456
  • [22] Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells
    Arias, Consuelo
    Sepulveda, Paulina
    Castillo, Rodrigo L.
    Salazar, Luis A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (04)
  • [23] The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
    Khor, Bernard
    Gagnon, John D.
    Goel, Gautam
    Roche, Marly I.
    Conway, Kara L.
    Tran, Khoa
    Aldrich, Leslie N.
    Sundberg, Thomas B.
    Paterson, Alison M.
    Mordecai, Scott
    Dombkowski, David
    Schirmer, Melanie
    Tan, Pauline H.
    Bhan, Atul K.
    Roychoudhuri, Rahul
    Restifo, Nicholas P.
    O'Shea, John J.
    Medoff, Benjamin D.
    Shamji, Alykhan F.
    Schreiber, Stuart L.
    Sharpe, Arlene H.
    Shaw, Stanley Y.
    Xavier, Ramnik J.
    ELIFE, 2015, 4 : 1 - 27
  • [24] MicroRNA-155 Modulates Treg and Th17 Cells Differentiation and Th17 Cell Function by Targeting SOCS1
    Yao, Rui
    Ma, Yu-Lan
    Liang, Wei
    Li, Huan-Huan
    Ma, Zhi-Jun
    Yu, Xian
    Liao, Yu-Hua
    PLOS ONE, 2012, 7 (10):
  • [25] HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    Shi, Lewis Z.
    Wang, Ruoning
    Huang, Gonghua
    Vogel, Peter
    Neale, Geoffrey
    Green, Douglas R.
    Chi, Hongbo
    JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (07): : 1367 - 1376
  • [26] HDAC6-specific inhibitor suppresses Th17 cell function via the HIF-1α pathway in acute lung allograft rejection in mice
    Zhou, Wenyong
    Yang, Jun
    Saren, Gaowa
    Zhao, Heng
    Cao, Kejian
    Fu, Shijie
    Pan, Xufeng
    Zhang, Huijun
    Wang, An
    Chen, Xiaofeng
    THERANOSTICS, 2020, 10 (15): : 6790 - 6805
  • [27] TL1A, a TNF-like molecule, regulates the differentiation of human TH17 cells
    Michelsen, Kathrin
    Yu, Qi
    Ko, Brian
    Thomas, Lisa
    Takedatsu, Hidetoshi
    Landers, Carol
    Targan, Stephan
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [28] Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis
    Jun Huang
    Zhuang Li
    Yunwei Hu
    Zuoyi Li
    Yanyan Xie
    Haixiang Huang
    Qian Chen
    Guanyu Chen
    Wenjie Zhu
    Yuxi Chen
    Wenru Su
    Xiaoqing Chen
    Dan Liang
    Journal of Neuroinflammation, 19
  • [29] Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis
    Huang, Jun
    Li, Zhuang
    Hu, Yunwei
    Li, Zuoyi
    Xie, Yanyan
    Huang, Haixiang
    Chen, Qian
    Chen, Guanyu
    Zhu, Wenjie
    Chen, Yuxi
    Su, Wenru
    Chen, Xiaoqing
    Liang, Dan
    JOURNAL OF NEUROINFLAMMATION, 2022, 19 (01)
  • [30] Costunolide ameliorates colitis via specific inhibition of HIF1α/glycolysis-mediated Th17 differentiation
    Lv, Qi
    Xing, Yao
    Dong, Dong
    Hu, Yang
    Chen, Qingzhu
    Zhai, Linhui
    Hu, Lihong
    Zhang, Yinan
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 97