Behavioral and neuroreceptor differences in C57BL/6 and BALB/c mice

被引：0
|
作者：
G. I. Kovalev
E. A. Kondrakhin
R. M. Salimov
机构：
[1] Russian Academy of Medical Sciences,Zakusov Research Institute of Pharmacology
来源：
Neurochemical Journal | 2013年 / 7卷
关键词：
NMDA receptor; benzodiazepine receptor; cross-maze test; radioligand binding; exploratory behavior; anxiety; correlation analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied spontaneous behavior in the cross-maze test and differences in neuroreceptors in inbred C57BL/6 and BALB/c mice. Correlation and factor analysis of behavioral data showed that the indices of exploratory behavior and anxiety in a novel context were rather independent from each other. The densities of NMDA receptors (Bmax, fmol/mg of protein) in the hippocampus and benzodiazepine receptors in the prefrontal cortex were higher in C57BL/6 mice. Our data demonstrate the opportunity for selective pharmacological regulation of cognitive behavior and anxiety using nootropic and anxiolytic drugs.
引用
收藏
页码：121 / 127
页数：6
相关论文
共 50 条
  • [31] Mouse Parvovirus Infection in BALB/c, C57BL/6, and Swiss Webster Mice
    Macy, J. D.
    Paturzo, F. X.
    Compton, S. R.
    JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE, 2009, 48 (05): : 534 - 534
  • [32] Different Responses to Identical Trauma Between BALB/C and C57BL/6 Mice
    Chen, Xiuying
    Cheng, Chang
    Cheng, Wenchao
    Wang, Yuhan
    Zuo, Xuzheng
    Tang, Weiju
    Yu, Zhanyang
    Yang, Zhihuan
    Wang, Zhengguo
    Zhu, Peifang
    Huang, Wen
    MEDICAL SCIENCE MONITOR, 2021, 27
  • [33] Immunomodulation of inherent behavior in C57Bl/6 and BALB/c mice with antibodies to glutamate
    Trekova, NA
    Mikovskaya, OI
    Basharova, LA
    Vetrile, LA
    Evseev, VA
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2002, 133 (02) : 118 - 121
  • [34] Immunomodulation of Inherent Behavior in C57Bl/6 and BALB/c Mice with Antibodies to Glutamate
    N. A. Trekova
    O. I. Mikovskaya
    L. A. Basharova
    L. A. Vetrile
    V. A. Evseev
    Bulletin of Experimental Biology and Medicine, 2002, 133 : 118 - 121
  • [35] Susceptibility to immunologically mediated fatigue in C57BL/6 versus Balb/c mice
    Sheng, WS
    Hu, SX
    Lamkin, A
    Peterson, PK
    Chao, CC
    CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 81 (02): : 161 - 167
  • [36] The amount of cage bedding preferred by female BALB/c and C57BL/6 mice
    Freymann, Jennifer
    Tsai, Ping-Ping
    Stelzer, Helge
    Hackbarth, Hansjoachim
    LAB ANIMAL, 2015, 44 (01) : 27 - 32
  • [37] Behavioral changes in aging female C57BL/6 mice
    Fahlstrom, Andreas
    Yu, Qian
    Ulfahke, Brun
    NEUROBIOLOGY OF AGING, 2011, 32 (10) : 1868 - 1880
  • [38] Behavioral Effect of Terahertz Waves in C57BL/6 Mice
    Qi, Miao
    Liu, Rong
    Li, Bing
    Wang, Shuai
    Fan, Runze
    Zhao, Xinyi
    Xu, Dehui
    BIOSENSORS-BASEL, 2022, 12 (02):
  • [39] Bronchial lesions of the late asthmatic response in BALB/c and C57BL/6 mice
    Hayashi, T
    Hasegawa, K
    Nakai, S
    Hamachi, T
    Adachi, Y
    Yamauchi, Y
    Maeda, K
    JOURNAL OF COMPARATIVE PATHOLOGY, 2001, 125 (2-3) : 208 - 213
  • [40] The amount of cage bedding preferred by female BALB/c and C57BL/6 mice
    Freymann J.
    Tsai P.-P.
    Stelzer H.
    Hackbarth H.
    Lab Animal, 2015, 44 (1) : 17 - 22
12345