Behavioral and neuroreceptor differences in C57BL/6 and BALB/c mice

被引：0
|
作者：
G. I. Kovalev
E. A. Kondrakhin
R. M. Salimov
机构：
[1] Russian Academy of Medical Sciences,Zakusov Research Institute of Pharmacology
来源：
Neurochemical Journal | 2013年 / 7卷
关键词：
NMDA receptor; benzodiazepine receptor; cross-maze test; radioligand binding; exploratory behavior; anxiety; correlation analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied spontaneous behavior in the cross-maze test and differences in neuroreceptors in inbred C57BL/6 and BALB/c mice. Correlation and factor analysis of behavioral data showed that the indices of exploratory behavior and anxiety in a novel context were rather independent from each other. The densities of NMDA receptors (Bmax, fmol/mg of protein) in the hippocampus and benzodiazepine receptors in the prefrontal cortex were higher in C57BL/6 mice. Our data demonstrate the opportunity for selective pharmacological regulation of cognitive behavior and anxiety using nootropic and anxiolytic drugs.
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页码：121 / 127
页数：6
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