A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

被引：0
|
作者：
Xiangxi Wang
Wei Peng
Jingshan Ren
Zhongyu Hu
Jiwei Xu
Zhiyong Lou
Xumei Li
Weidong Yin
Xinliang Shen
Claudine Porta
Thomas S Walter
Gwyndaf Evans
Danny Axford
Robin Owen
David J Rowlands
Junzhi Wang
David I Stuart
Elizabeth E Fry
Zihe Rao
机构：
[1] National Laboratory of Macromolecules,Division of Structural Biology
[2] Institute of Biophysics,undefined
[3] Chinese Academy of Science,undefined
[4] University of Oxford,undefined
[5] The Henry Wellcome Building for Genomic Medicine,undefined
[6] National Institutes for Food and Drug Control,undefined
[7] No. 2 Tiantan Xili,undefined
[8] Beijing,undefined
[9] China.,undefined
[10] Laboratory of Structural Biology,undefined
[11] School of Medicine,undefined
[12] Tsinghua University,undefined
[13] Diamond Light Sources,undefined
[14] Harwell Science and Innovation Campus,undefined
[15] Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology,undefined
[16] Faculty of Biological Sciences,undefined
[17] University of Leeds,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
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摘要：
Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of the mature virus and natural empty particles reveals that the larger empty particles resemble elusive enterovirus uncoating intermediates, allowing insight into the process of enterovirus uncoating.
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页码：424 / 429
页数：5
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