A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

被引：0

作者：

Xiangxi Wang

Wei Peng

Jingshan Ren

Zhongyu Hu

Jiwei Xu

Zhiyong Lou

Xumei Li

Weidong Yin

Xinliang Shen

Claudine Porta

Thomas S Walter

Gwyndaf Evans

Danny Axford

Robin Owen

David J Rowlands

Junzhi Wang

David I Stuart

Elizabeth E Fry

Zihe Rao

机构：

[1] National Laboratory of Macromolecules,Division of Structural Biology

[2] Institute of Biophysics,undefined

[3] Chinese Academy of Science,undefined

[4] University of Oxford,undefined

[5] The Henry Wellcome Building for Genomic Medicine,undefined

[6] National Institutes for Food and Drug Control,undefined

[7] No. 2 Tiantan Xili,undefined

[8] Beijing,undefined

[9] China.,undefined

[10] Laboratory of Structural Biology,undefined

[11] School of Medicine,undefined

[12] Tsinghua University,undefined

[13] Diamond Light Sources,undefined

[14] Harwell Science and Innovation Campus,undefined

[15] Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology,undefined

[16] Faculty of Biological Sciences,undefined

[17] University of Leeds,undefined

来源：

Nature Structural & Molecular Biology | 2012年 / 19卷

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摘要：

Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of the mature virus and natural empty particles reveals that the larger empty particles resemble elusive enterovirus uncoating intermediates, allowing insight into the process of enterovirus uncoating.

引用

页码：424 / 429

页数：5

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