The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

被引：0

作者：

Mamta Tahiliani

Pinchao Mei

Rui Fang

Thiago Leonor

Michael Rutenberg

Fumiko Shimizu

Jing Li

Anjana Rao

Yujiang Shi

机构：

[1] Diabetes,Division of Endocrinology, Department of Medicine and BCMP

[2] and Hypertension,Department of Pathology

[3] Brigham and Women's Hospital and Harvard Medical School,undefined

[4] 221 Longwood Avenue,undefined

[5] Harvard Medical School and the CBR Institute for Biomedical Research,undefined

[6] 200 Longwood Avenue,undefined

[7] Boston,undefined

[8] Massachusetts 02115,undefined

[9] USA,undefined

[10] University of Florida College of Medicine,undefined

[11] Gainesville,undefined

[12] Florida 32610,undefined

[13] USA,undefined

来源：

Nature | 2007年 / 447卷

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学科分类号：

摘要：

A protein previously implicated in X-linked mental retardation has now been found to influence gene expression by modifying histones. The JmjC-domain-containing protein SMCX (or JARID1C) is a histone demethylase that demethylates H3 trimethylated at lysine 4, both in vitro and in cells, and can repress transcription of certain neuronal genes. The finding suggests that mutations in SMCX might contribute to disease by impairing regulation of neuronal genes via this effect on chromatin.

引用

页码：601 / 605

页数：4

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