Modification of biologically active amides and amines with fluorine-containing heterocycles 7. Fluorine-containing heterocyclic derivatives of the acetazolamide

被引：0
|
作者：
V. B. Sokolov
A. Yu. Aksinenko
机构：
[1] Russian Academy of Sciences,Institute of Physiologically Active Substances
来源：
Russian Chemical Bulletin | 2012年 / 61卷
关键词：
acetazolamide; methyl trifluoropyruvate; 6-aminouracils; 6-aminothiouracils; -substituted ureas; fluorine-containing hexahydro-1; -pyrrolo[2,3-; ]pyrimidines; 2,5-dioxo-imidazolidines; cyclocondensation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An approach is proposed to modification of a medical product acetazolamide (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide) by interaction of 2-(5-acetylamino-1,3,4-thiadiazole-2-yl)sulfonyl imine methyl trifluoropyruvate, which is in-situ generated from acetazolamide, with 1,3-binucleophiles: 6-aminouracils, 6-aminothiouracils, and N-substituted ureas, to yield heterocyclic compounds with the CF3 substituent in the nitrogen-containing mono- or bicycle.
引用
收藏
页码：2124 / 2128
页数：4
相关论文
共 50 条
  • [21] Modification of biologically active amides and amines with fluorine-containing heterocycles 3*. Piracetam in the three-component reaction with methyl trifluoropyruvate and 1,3-binucleophiles
    V. B. Sokolov
    A. Yu. Aksinenko
    T. A. Epishina
    T. V. Goreva
    I. V. Martynov
    Russian Chemical Bulletin, 2010, 59 : 288 - 291
  • [22] STUDIES ON FLUORINE-CONTAINING AROMATIC HETEROCYCLIC-COMPOUNDS .7. THE SYNTHESES OF FLUORINE-CONTAINING AZA-DIBENZO, THIA-DIBENZO CROWN COMPOUNDS
    CHEN, DH
    HUANG, JH
    HUANG, Q
    JI, JS
    HUANG, XL
    YANG, Y
    XU, HS
    ACTA CHIMICA SINICA, 1993, 51 (07) : 702 - 707
  • [23] FLUORINE-CONTAINING POLY(ETHER-AMIDES)
    CASSIDY, PE
    THAEMLITZ, CJ
    BREWER, KW
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 200 : 183 - POLY
  • [24] Synthesis of fluorine-containing benzimidazole derivatives
    Vasilyeva, T. P.
    Karimova, N. M.
    Slavich, Yu. V.
    RUSSIAN CHEMICAL BULLETIN, 2010, 59 (01) : 186 - 191
  • [25] FLUORINE-CONTAINING DERIVATIVES OF PYRIMIDINE AND IMIDAZOLE
    IGUMNOV, SM
    SOTNIKOV, NV
    SOKOLSKII, GA
    KNUNYANTS, IL
    ZHURNAL VSESOYUZNOGO KHIMICHESKOGO OBSHCHESTVA IMENI D I MENDELEEVA, 1981, 26 (01): : 97 - 98
  • [26] Fluorine-containing α-Dicarbonyl Compounds and Their Derivatives
    Saloutin, V.I.
    Pashkevich, K.I.
    Postovskii, I.Ya.
    Russian Chemical Reviews, 1982, 51 (08) : 736 - 745
  • [27] New derivatives of fluorine-containing phenazines
    Filyakova, Tatjana I.
    Filyakova, Vera I.
    Zapevalov, Alexander Ya.
    Kodess, Mikhail I.
    Slepukhin, Pavel A.
    Saloutin, Victor I.
    Charushin, Valery N.
    MENDELEEV COMMUNICATIONS, 2017, 27 (03) : 290 - 292
  • [28] Synthesis of fluorine-containing benzimidazole derivatives
    T. P. Vasilyeva
    N. M. Karimova
    Yu. V. Slavich
    Russian Chemical Bulletin, 2010, 59 : 186 - 191
  • [29] Mechanically active fluorine-containing polymers
    Klukovich, Hope
    Craig, Stephen L.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [30] FLUORINE-CONTAINING DIVINYLBENZENES
    PANOV, EM
    SOROKINA, RS
    KOCHESHK.KA
    JOURNAL OF GENERAL CHEMISTRY USSR, 1965, 35 (08): : 1430 - &
12345