Modification of biologically active amides and amines with fluorine-containing heterocycles 7. Fluorine-containing heterocyclic derivatives of the acetazolamide

被引：0
|
作者：
V. B. Sokolov
A. Yu. Aksinenko
机构：
[1] Russian Academy of Sciences,Institute of Physiologically Active Substances
来源：
Russian Chemical Bulletin | 2012年 / 61卷
关键词：
acetazolamide; methyl trifluoropyruvate; 6-aminouracils; 6-aminothiouracils; -substituted ureas; fluorine-containing hexahydro-1; -pyrrolo[2,3-; ]pyrimidines; 2,5-dioxo-imidazolidines; cyclocondensation;
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学科分类号：
摘要：
An approach is proposed to modification of a medical product acetazolamide (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide) by interaction of 2-(5-acetylamino-1,3,4-thiadiazole-2-yl)sulfonyl imine methyl trifluoropyruvate, which is in-situ generated from acetazolamide, with 1,3-binucleophiles: 6-aminouracils, 6-aminothiouracils, and N-substituted ureas, to yield heterocyclic compounds with the CF3 substituent in the nitrogen-containing mono- or bicycle.
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页码：2124 / 2128
页数：4
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