Synthesis and Anthelmintic and Insecticidal Activities of 1-R-3-Methyl-6-Methoxy-7-( P-Propoxy)-3,4-Dihydroisoquinoline Hydrochlorides

被引：0
|
作者：
O. V. Surikova
A. G. Mikhailovskii
B. Ya. Syropyatov
A. S. Yusov
机构：
[1] Perm State Pharmaceutical Academy,
来源：
Pharmaceutical Chemistry Journal | 2017年 / 50卷
关键词：
cyclocondensation of ; -; -propyleugenol with nitriles; 1-; -3-methyl-6-methoxy-7-(; -propoxy)-3,4-dihydroisoquinoline hydrochlorides; anthelmintic and insecticidal activity;
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摘要：
1-R-3-Methyl-6-methoxy-7-(n-propoxy)-3,4-dihydroisoquinolines were synthesized via cyclocondensation of O-n-propyleugenol with various nitriles. It was shown that the hydrochlorides of the synthesized compounds exhibited anthelmintic and weak insecticidal activity. The isoquinoline containing a 1-benzyl radical had the greatest anthelmintic activity and was more potent than pyrantel and imidacloprid.
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页码：794 / 797
页数：3
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