Polymer Nanoparticles Prepared by Supercritical Carbon Dioxide for in Vivo Anti-cancer Drug Delivery

被引：0
|
作者：
Maofang Hua
Xiufu Hua
机构：
[1] Lianyungang Maternal and Child Health Hospital,Department of Scientific Research and Development
[2] Tsinghua University,undefined
来源：
Nano-Micro Letters | 2014年 / 6卷
关键词：
Protein; Polymer; Nanoparticle; Drug delivery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new approach for producing polymer nanoparticles made of bovine serum albumin-poly(methyl methacrylate) conjugate by precipitating in supercritical CO2 is reported. The nanoparticles were loaded with the anti-tumor drug camptothecin. With albumin serving as a nutrient to cells, the drug-encapsulated nanoparticle shows an enhanced ability to kill cancer cells compared to that of the free drug in solution both in vitro and in vivo.
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页码：20 / 23
页数：3
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