4849F, a New Metabolite Produced by the Streptomyces sp. 4849 as an Inhibitor of IL-4 Receptor

被引：0
|
作者：
Ke Wang
Lianhong Guo
Yingshu Zou
Yuan Li
Jianbo Wu
机构：
[1] Institute of Medicinal Biotechnology,
[2] Chinese Academy of Medical Science & Peking Union Medical College,undefined
来源：
The Journal of Antibiotics | 2007年 / 60卷
关键词：
4849F; IL-4; IL-4R; inhibitor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new compound named 4849F was isolated from the Streptomyces sp. 4849. The structure of 4849F was elucidated by spectroscopic analyses. The immobilized ligand-binding assay showed that 4849F can competitively inhibit the binding of IL-4 with IL-4 receptor in a dose dependent manner with an IC50 value of 6.7 μM.
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页码：325 / 327
页数：2
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