Evaluation of piperine analogs against prostate cancer targeting AKT1 kinase domain through network pharmacological analysis

被引:1
|
作者
Nayana Prakash
机构
[1] Kuvempu University,Department of PG Studies and Research in Biotechnology
关键词
Piperine; Akt1; preADMET; pip2; In silico methods; AutoDock Vina;
D O I
10.1007/s40203-023-00145-5
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 37 条
  • [31] Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells
    Misra, Uma K.
    Pizzo, Salvatore V.
    CANCER BIOLOGY & THERAPY, 2010, 9 (02) : 142 - 152
  • [32] PROTEIN KINASE D1 (PRKD) PROTECTS AGAINST DNA DAMAGE BY INCREASING A-CATENIN LEVELS THROUGH PUTATIVE SERINE681 AND 685 PHOSPHORYLATION OF CYCLIN DEPENDENT KINASE 12 (CDK12) IN PROSTATE CANCER (PC)
    Shukla, Sanjeev
    Osumi, Teruko
    Al-Toubat, Mohammed
    Riveros, Carlos
    Feibus, Allison H.
    El-Shafie, Ahmed
    Kase, Adam M.
    Copland, John A., III
    Petit, Joachim L.
    Meurice, Nathalie
    Gleba, Justyna
    Chardon-Robles, Jonathan
    Balaji, K. C.
    JOURNAL OF UROLOGY, 2023, 209 : E275 - E275
  • [33] Microarray pathway analysis indicated that mitogen-activated protein kinase/extracellular signal-regulated kinase and insulin growth factor 1 signaling pathways were inhibited by small interfering RNA against AT-rich interactive domain 1A in endometrial cancer
    Yang, Ye
    Bao, Wei
    Sang, Zhengyu
    Yang, Yongbing
    Lu, Meng
    Xi, Xiaowei
    ONCOLOGY LETTERS, 2018, 15 (02) : 1829 - 1838
  • [34] Targeting the p300/CBP interactome through blockage of the CH1-domain triggers tumor regression in AR-positive and AR-negative xenograft models of castration-resistant prostate cancer (CRPC).
    Cattori, Valentino
    Hentsch, Bernd
    Kessler, Ulrich
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [35] Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types
    Mokgautsi, Ntlotlang
    Wang, Yu-Chi
    Lawal, Bashir
    Khedkar, Harshita
    Sumitra, Maryam Rachmawati
    Wu, Alexander T. H.
    Huang, Hsu-Shan
    CANCERS, 2021, 13 (11)
  • [36] Structural analogs of 2-(4-fluorophenyl)-6-methyl-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine for targeting Candida albicans non-essential stress kinase Yck2 through protein-ligand binding and dynamics analysis
    Hassan, Ahmed M.
    Khateb, Aiah M.
    Turkistani, Safaa A.
    Alhamdan, Meshari M.
    Garout, Raed M.
    Dwivedi, Vivek Dhar
    Azhar, Esam I.
    FRONTIERS IN CHEMISTRY, 2024, 12
  • [37] GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study
    Sarkar, Chandan
    Mondal, Milon
    Al-Khafaji, Khattab
    El-Kersh, Dina M.
    Jamaddar, Sarmin
    Ray, Pranta
    Roy, Uttam Kumar
    Afroze, Mirola
    Moniruzzaman, Md
    Khan, Mala
    Asha, Umma Hafsa
    Khalipha, Abul Bashar Ripon
    Mori, Edna
    Goncalves Vasconcelos de Lacerda, Bruna Caroline
    Araujo, Isaac Moura
    Melo Coutinho, Henrique Douglas
    Shill, Manik Chandra
    Islam, Muhammad Torequl
    LIFE SCIENCES, 2022, 309