Attenuation of neurovirulence of chikungunya virus by a single amino acid mutation in viral E2 envelope protein

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作者
Huixin Chen
Patchara Phuektes
Li Sze Yeo
Yi Hao Wong
Regina Ching Hua Lee
Bowen Yi
Xinjun Hou
Sen Liu
Yu Cai
Justin Jang Hann Chu
机构
[1] National University of Singapore,Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine
[2] National University of Singapore,Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine
[3] Institute of Molecular and Cell Biology,Collaborative and Translation Unit for HFMD
[4] Agency for Science,Division of Pathobiology, Faculty of Veterinary Medicine
[5] Technology and Research (A*STAR),School of Applied Science
[6] Khon Kaen University,Temasek Life Sciences Laboratory
[7] Republic Polytechnic,Department of Biological Sciences
[8] National University of Singapore,undefined
[9] National University of Singapore,undefined
关键词
Chikungunya virus; Plaque size; Neurovirulence; Pathogenesis; Attenuation;
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