Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis

被引:0
|
作者
Su-jong Yu
Jung-hwan Yoon
Jeong-hoon Lee
Sun-jung Myung
Eun-sun Jang
Min-sun Kwak
Eun-ju Cho
Ja-june Jang
Yoon-jun Kim
Hyo-suk Lee
机构
[1] Seoul National University College of Medicine,Department of Internal Medicine and Liver Research Institute
[2] Seoul National University College of Medicine,Department of Pathology
来源
关键词
hepatocellular carcinoma; hypoxia; intracellular acidification; carbonic anhydrase-IX; hexokinase II; apoptosis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:912 / 920
页数:8
相关论文
共 28 条
  • [21] Pax8, hypoxia-inducible protein 2 (hig2), KSP-cadherin and carbonic anhydrase IX (CAIX) expression in collecting duct renal cell carcinoma (CDRCC) and papillary renal cell carcinoma (PRCC)
    Abdullazade, S.
    Schultz, L.
    Netto, G.
    Illei, P.
    Sharma, R.
    Albadine, R.
    Baydar, Ertoy D.
    VIRCHOWS ARCHIV, 2009, 455 : 147 - 147
  • [22] THE MOLECULAR MECHANISMS OF TYPE-2 GLUCOSE TRANSPORTER INHIBITOR-INDUCED APOPTOSIS IN HUMAN HEPATOCELLULAR CARCINOMA CELL
    Ho, Yuan-Soon
    Wu, Chih-Hsiung
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 495 - 495
  • [23] TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis
    Zeng, Lihua
    Ou, Guangfei
    Itasaka, Satoshi
    Harada, Hiroshi
    Xie, Xuejun
    Shibuya, Keiko
    Kizaka-Kondoh, Shinae
    Morinibu, Akiyo
    Shinomiya, Kazumi
    Hiraoka, Masahiro
    CANCER SCIENCE, 2008, 99 (11) : 2327 - 2335
  • [24] Hypoxia-Inducible Factor-1α Suppressed Hepatocellular Carcinoma Cell Apoptosis Through Influencing on Omi/HtrA2 Expression and Its Releasing From the Mitochondrion
    Xu, Zongquan
    Chen, Xiaoping
    Peng, Cheng
    Liu, Enyu
    Li, Yunguang
    Li, Changhai
    Niu, Jun
    ONCOLOGY RESEARCH, 2012, 20 (5-6) : 213 - 220
  • [25] Phase II study of the oral hypoxia-inducible factor 2α (HIF-2 α) inhibitor MK-6482 in combination with cabozantinib in patients with advanced clear cell renal cell carcinoma (ccRCC)
    Tykodi, Scott S.
    Bauer, Todd Michael
    McDermott, David F.
    Arrowsmith, Edward
    Zojwalla, Naseem J.
    Choueiri, Toni K.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (06)
  • [26] Phase II study of belzutifan (MK-6482), an oral hypoxia-inducible factor 2α (HIF-2α) inhibitor, plus cabozantinib for treatment of advanced clear cell renal cell carcinoma (ccRCC)
    McDermott, D. F.
    Choueiri, T. K.
    Bauer, T. M.
    Arrowsmith, E.
    Roy, A.
    Perini, R.
    Vickery, D.
    Tykodi, S. S.
    ANNALS OF ONCOLOGY, 2021, 32 : S681 - S681
  • [27] Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells
    Li, Hongyan
    Jin, Xuefei
    Zhang, Zhuo
    Xing, Yuanyuan
    Kong, Xiangbo
    CELL BIOCHEMISTRY AND FUNCTION, 2013, 31 (05) : 427 - 433
  • [28] Phase II study of the oral hypoxia-inducible factor 2[alpha] (HIF-2[alpha]) inhibitor MK-6482 for Von Hippel-Lindau (VHL) disease-associated clear cell renal cell carcinoma (ccRCC).
    Iliopoulos, Othon
    Jonasch, Eric
    Donskov, Frede
    Narayan, Vivek
    Maughan, Benjamin Louis
    Oudard, Stephane
    Else, Tobias
    Maranchie, Jodi K.
    Welsh, Sarah J.
    Thamake, Sanjay
    Perini, Rodolfo F.
    Park, Eric Kristopher
    Linehan, Marston W.
    Srinivasan, Ramaprasad
    Rathmell, Kimryn W.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (06)