Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives

被引：0
|
作者：
Mahmoud Farouk
Salman A. Alrokayan
Ahamad Imran
Khalid M. Abu-Salah
Mohamed Ghazzali
Khalid A. Al-Farhan
Salem El-Gohary
Mamdouh Adly
机构：
[1] Salman Bin Abdalaziz University,College of Sciences & Humanity studies
[2] King Saud University,Centre of Excellence in Biotechnology Research
[3] King Saud University,Research Chair of Targeting and Treatment of Cancer Using Nanoparticles, King Abdullah Institute for Nanotechnology
[4] King Saud University,Chemistry Department, College of Science
[5] South Valley University,Chemistry Department, Faculty of Science
来源：
Chemical Papers | 2013年 / 67卷
关键词：
3-nitrophthalic acid anhydride; -hydroxy-3-nitrophthalimide; -sulphonyloxy-3-nitrophthalimide; 3-substitued quinazoline-2,4(1; ,3; )-diones; 2,3-disubstituted quinazolinones;
D O I：
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中图分类号：
学科分类号：
摘要：
3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II–III, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV–XIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII–XIX.
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页码：229 / 235
页数：6
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