The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy

被引：8
|
作者：
Li, Xu Qin [1 ]
机构：
[1] Univ Sci & Technol Beijing, Sch Appl Sci, Beijing 100083, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 10期
关键词：
Quinazolinediones; Carbonylation; Cyclization; Boc strategy; EFFICIENT; SCAFFOLD; AMPA;
D O I：
10.1016/j.cclet.2009.05.001
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities. A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide. Good to excellent yields have been achieved. (C) 2009 Xu Qin Li. Pubhshed by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1201 / 1203
页数：3
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