The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy

被引：8
|
作者：
Li, Xu Qin [1 ]
机构：
[1] Univ Sci & Technol Beijing, Sch Appl Sci, Beijing 100083, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 10期
关键词：
Quinazolinediones; Carbonylation; Cyclization; Boc strategy; EFFICIENT; SCAFFOLD; AMPA;
D O I：
10.1016/j.cclet.2009.05.001
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities. A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide. Good to excellent yields have been achieved. (C) 2009 Xu Qin Li. Pubhshed by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1201 / 1203
页数：3
相关论文
共 50 条
  • [31] Synthesis, Characterization, and Pharmacokinetic Studies of Thiazolidine-2,4-Dione Derivatives
    Ansari, Bushra
    Khan, Haroon
    Jan, Muhammad Saeed
    Alsharif, Khalaf F.
    Alzahrani, Khalid J.
    Rashid, Umer
    Pirzada, Abdul Saboor
    JOURNAL OF CHEMISTRY, 2023, 2023
  • [32] Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential
    Khoumeri, Omar
    Hutter, Sebastien
    Primas, Nicolas
    Castera-Ducros, Caroline
    Carvalho, Sandra
    Wyllie, Susan
    Efrit, Mohamed Lotfi
    Fayolle, Dimitri
    Since, Marc
    Vanelle, Patrice
    Verhaeghe, Pierre
    Azas, Nadine
    El-Kashef, Hussein
    PHARMACEUTICALS, 2024, 17 (07)
  • [33] Synthesis, characterization, and biological evaluation of thiazolidine-2,4-dione derivatives
    Shankar G. Alegaon
    Kallanagouda R. Alagawadi
    Sneha M. Pawar
    D. Vinod
    Udaysingh Rajput
    Medicinal Chemistry Research, 2014, 23 : 987 - 994
  • [34] THE SYNTHESIS OF ADAMANTANE-2,4-DIONE
    GILBERT, EE
    SYNTHETIC COMMUNICATIONS, 1985, 15 (01) : 53 - 56
  • [35] A practical solid phase synthesis of quinazoline-2,4-diones
    Shao, H
    Colucci, M
    Tong, SJ
    Zhang, HS
    Castelhano, AL
    TETRAHEDRON LETTERS, 1998, 39 (40) : 7235 - 7238
  • [36] Synthesis of some quinazoline-2(1H),4(3H)-dione derivatives
    Abdel-Razik, HH
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2005, 52 (01) : 141 - 148
  • [37] Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives
    Abid Hussain
    Muhammad Kalim Kashif
    Muhammad Moazzam Naseer
    Usman A. Rana
    Shahid Hameed
    Research on Chemical Intermediates, 2015, 41 : 7313 - 7326
  • [38] Synthesis and Biological Activities of New Series of Imidazolidin-2,4-dione Derivatives
    Nasser, A. Jamal Abdul
    Idhayadhulla, A.
    Kumar, R. Surendra
    Selvin, J.
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (08) : 5853 - 5858
  • [39] Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives
    da Silva, Ivanildo Mangueira
    da Silva Filho, Joao
    da Silva Santiago, Priscila Brandao Gomes
    do Egito, Micalyne Soares
    de Souza, Carlos Andre
    Gouveia, Frederico Leite
    Ximenes, Rafael Matos
    da Fonseca Ribeiro de Sena, Kesia Xisto
    de Faria, Antonio Rodolfo
    Brondani, Dalci Jose
    Cavalcanti de Albuquerque, Julianna Ferreira
    BIOMED RESEARCH INTERNATIONAL, 2014, 2014
  • [40] Synthesis of Novel Imidazolidine-2,4-dione Derivatives as Potential Antidiabetic Agents
    Cheng, Xian-Chao
    Sun, Su-Xia
    Zhang, Hao
    Dong, Wei-Li
    Liu, Gui-You
    Wang, Run-Ling
    Xu, Wei-Ren
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (09) : 4114 - 4116
12345