Since China opening to outside world, the economy in the Pearl (Zhujiang) River Delta (PRD) has been double digit growth. It has been known as one of mature fast growth areas in the world and become the model and hope of Chinese reform and opening to outside world. The regional development in PRD is the outcome of polarization effects. The polarization effects actually are extension of international regional division and a combination of Hongkong’s influence and reform and open-door policies on the mainland. Since the 1990s, driven by knowledge-based economy, the PRD has further adjusted the industrial structure and achieved good progress in upgrading industrial structure. Its high technology industry has developed quickly and the economic internationalization has deepened, meanwhile, the region is going through transformation and some new trends have begun to appear, which include: university towns springing up, industrial globalization and the construction of Hi-tech development zones. The paper suggests that with the economic growth changing from relying on the low level production elements to relying on high level production elements, the regional policies in Guangdong Province should develop correspondingly: 1) make a plan to prohibite the blind construction in innovative spatial constructions; 2) make measures to attract the overseas talents to establish a pool of talent; 3) work out the favorable policies for absorbing larger capital; 4) formulate the policy of attracting a cluster of industries to speed up the upgrade of industrial development.