CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest

被引：0
|
作者：
Jiayuan Wang
Qingqing Li
Jiajia Yuan
Jingyuan Wang
Zuhua Chen
Zhentao Liu
Zhongwu Li
Yumei Lai
Jing Gao
Lin Shen
机构：
[1] Peking University Cancer Hospital and Institute,Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)
[2] Peking University Cancer Hospital and Institute,Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)
来源：
Journal of Translational Medicine | / 15卷
关键词：
CDK4/6 inhibitor; ESCC; Cell cycle arrest; pRb;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest
    Wang, Jiayuan
    Li, Qingqing
    Yuan, Jiajia
    Wang, Jingyuan
    Chen, Zuhua
    Liu, Zhentao
    Li, Zhongwu
    Lai, Yumei
    Gao, Jing
    Shen, Lin
    JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15
  • [2] The CDK4/6 inhibitor has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma
    Ku, Bo Mi
    Koh, Jiae
    Bae, Yeon-Hee
    Sun, Jong-Mu
    Lee, Se-hoon
    Ahn, Jin Seok
    Park, Keunchil
    Ahn, Myung-Ju
    CANCER RESEARCH, 2016, 76
  • [3] The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest
    Cheng, Yin-Wei
    Liao, Lian-Di
    Yang, Qian
    Chen, Yang
    Nie, Ping-Juan
    Zhang, Xiao-Jun
    Xie, Jian-Jun
    Shan, Bao-En
    Zhao, Lian-Mei
    Xu, Li-Yan
    Li, En-Min
    CELL BIOCHEMISTRY AND FUNCTION, 2018, 36 (08) : 398 - 407
  • [4] CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition
    Kim, Sungsoo
    Leong, Alessandra
    Kim, Minah
    Yang, Hee Won
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [5] CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition
    Sungsoo Kim
    Alessandra Leong
    Minah Kim
    Hee Won Yang
    Scientific Reports, 12
  • [6] Dronedarone inhibits the proliferation of esophageal squamous cell carcinoma through the CDK4/CDK6-RB1 axis in vitro and in vivo
    Li, Bo
    Zhang, Jing
    Yu, Yin
    Li, Yinhua
    Chen, Yingying
    Zhao, Xiaokun
    Li, Ang
    Zhao, Lili
    Li, Mingzhu
    Wang, Zitong
    Lu, Xuebo
    Wu, Wenjie
    Zhang, Yueteng
    Dong, Zigang
    Liu, Kangdong
    Jiang, Yanan
    FRONTIERS OF MEDICINE, 2024, 18 (05) : 896 - 910
  • [7] The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma
    Ku, Bo Mi
    Yi, Seong Yoon
    Koh, Jiae
    Bae, Yeon-Hee
    Sun, Jong-Mu
    Lee, Se-Hoon
    Ahn, Jin Seok
    Park, Keunchil
    Ahn, Myung-Ju
    ONCOTARGET, 2016, 7 (12) : 14803 - 14813
  • [8] AZD2014 Radiosensitizes Oral Squamous Cell Carcinoma by Inhibiting AKT/mTOR Axis and Inducing G1/G2/M Cell Cycle Arrest
    Yu, Chih-Chia
    Huang, Hsien-bin
    Hung, Shih-Kai
    Liao, Hui-Fen
    Lee, Ching-Chih
    Lin, Hon-Yi
    Li, Szu-Chin
    Ho, Hsu-Chueh
    Hung, Chung-Lin
    Su, Yu-Chieh
    PLOS ONE, 2016, 11 (03):
  • [9] Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
    Qie, Shuo
    Yoshida, Akihiro
    Parnham, Stuart
    Oleinik, Natalia
    Beeson, Gyda C.
    Beeson, Craig C.
    Ogretmen, Besim
    Bass, Adam J.
    Wong, Kwok-Kin
    Rustgi, Anil K.
    Diehl, J. Alan
    NATURE COMMUNICATIONS, 2019, 10
  • [10] Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
    Shuo Qie
    Akihiro Yoshida
    Stuart Parnham
    Natalia Oleinik
    Gyda C. Beeson
    Craig C. Beeson
    Besim Ogretmen
    Adam J. Bass
    Kwok-Kin Wong
    Anil K. Rustgi
    J. Alan Diehl
    Nature Communications, 10
12345