CD36 deficiency and absent myocardial iodine-123-(R,S)-15-(p-iodophenyl)-3-methylpentadecanoic acid uptake in a girl with cardiomyopathy

被引：0
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作者：
Masayuki Teraguchi
Hiroyuki Ohkohchi
Yumiko Ikemoto
Hirohiko Higashino
Yohnosuke Kobayashi
机构：
[1] Kansai Medical University,Department of Pediatrics
[2] Kansai Medical University Hospital,Department of Clinical Laboratory
来源：
European Journal of Pediatrics | 2003年 / 162卷
关键词：
CD36 deficiency; Long-chain fatty acid metabolism; Iodine-123-(; ,; )-15-(; -iodophenyl)-3-methylpentadecanoic acid; BMIPP; Pediatric cardiology;
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学科分类号：
摘要：
A 10-year-old girl presented left ventricular failure 1 month after the onset of hemolytic uremic syndrome (HUS) caused by an Escherichia coli O157 infection and was diagnosed as having dilated cardiomyopathy. Thallium myocardial scintigraphy showed normal perfusion, but no myocardial uptake of iodine-123-(R,S)-15-(p-iodophenyl)-3-methylpentadecanoic acid (123I-BMIPP) was observed. We analyzed the CD36 expression in platelets and monocytes by using a flowcytometer, and she turned out to have CD36 deficiency type I. Conclusion: Some patients may be predisposed to myocardial damage in the presence of CD36 deficiency. It is necessary to clarify the etiological significance of the relationship between cardiac impairment and CD36 deficiency in children.
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页码：264 / 266
页数：2
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