The power of large-scale exome sequencing

被引:0
|
作者
Linda Koch
机构
[1] Nature Reviews Genetics,
来源
Nature Reviews Genetics | 2021年 / 22卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Capturing rare protein-coding variation by whole-exome sequencing in large and diverse population samples can help identify large-effect associations and drug targets, suggest two recent publications.
引用
收藏
页码:549 / 549
相关论文
共 50 条
  • [21] An estimate of large-scale sequencing accuracy
    Hill, F
    Gemünd, C
    Benes, V
    Ansorge, W
    Gibson, TJ
    EMBO REPORTS, 2000, 1 (01) : 29 - 31
  • [22] Automation in large-scale DNA sequencing
    Buxton, EC
    Westphall, M
    Jacobson, W
    Tong, XC
    Smith, LM
    LABORATORY ROBOTICS AND AUTOMATION, 1996, 8 (06) : 339 - 349
  • [23] Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
    Deng, Yue-Ting
    Wu, Bang-Sheng
    Yang, Liu
    He, Xiao-Yu
    Kang, Ju-Jiao
    Liu, Wei-Shi
    Li, Ze-Yu
    Wu, Xin-Rui
    Zhang, Ya-Ru
    Chen, Shi-Dong
    Ge, Yi-Jun
    Huang, Yu-Yuan
    Feng, Jian-Feng
    Zhu, Ying
    Dong, Qiang
    Mao, Ying
    Cheng, Wei
    Yu, Jin-Tai
    NATURE HUMAN BEHAVIOUR, 2024, 8 (06) : 1194 - 1208
  • [25] A large-scale exome array analysis of venous thromboembolism
    Lindstrom, Sara
    Brody, Jennifer A.
    Turman, Constance
    Germain, Marine
    Bartz, Traci M.
    Smith, Erin N.
    Chen, Ming-Huei
    Puurunen, Marja
    Chasman, Daniel
    Hassler, Jeffrey
    Pankratz, Nathan
    Basu, Saonli
    Guan, Weihua
    Gyorgy, Beata
    Ibrahim, Manal
    Empana, Jean-Philippe
    Olaso, Robert
    Jackson, Rebecca
    Braekkan, Sigrid K.
    McKnight, Barbara
    Deleuze, Jean-Francois
    O'Donnell, Cristopher J.
    Jouven, Xavier
    Frazer, Kelly A.
    Psary, Bruce M.
    Wiggins, Kerri L.
    Taylor, Kent
    Reiner, Alexander P.
    Heckbert, Susan R.
    Kooperberg, Charles
    Ridker, Paul
    Hansen, John-Bjarne
    Tang, Weihong
    Johnson, Andrew D.
    Morange, Pierre-Emmanuel
    Tregouet, David A.
    Kraft, Peter
    Smith, Nicholas L.
    Kabrhel, Christopher
    GENETIC EPIDEMIOLOGY, 2019, 43 (04) : 449 - 457
  • [26] Exome Sequencing Followed by Large-Scale Genotyping Fails to Identify Single Rare Variants of Large Effect in Idiopathic Generalized Epilepsy
    Heinzen, Erin L.
    Depondt, Chantal
    Cavalleri, Gianpiero L.
    Ruzzo, Elizabeth K.
    Walley, Nicole M.
    Need, Anna C.
    Ge, Dongliang
    He, Min
    Cirulli, Elizabeth T.
    Zhao, Qian
    Cronin, Kenneth D.
    Gumbs, Curtis E.
    Campbell, C. Ryan
    Hong, Linda K.
    Maia, Jessica M.
    Shianna, Kevin V.
    McCormack, Mark
    Radtke, Rodney A.
    O'Conner, Gerard D.
    Mikati, Mohamad A.
    Gallentine, William B.
    Husain, Aatif M.
    Sinha, Saurabh R.
    Chinthapalli, Krishna
    Puranam, Ram S.
    McNamara, James O.
    Ottman, Ruth
    Sisodiya, Sanjay M.
    Delanty, Norman
    Goldstein, David B.
    AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 91 (02) : 293 - 302
  • [27] Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing
    Jansen, Iris E.
    Ye, Hui
    Heetveld, Sasja
    Lechler, Marie C.
    Michels, Helen
    Seinstra, Renee I.
    Lubbe, Steven J.
    Drouet, Valerie
    Lesage, Suzanne
    Majounie, Elisa
    Gibbs, J. Raphael
    Nalls, Mike A.
    Ryten, Mina
    Botia, Juan A.
    Vandrovcova, Jana
    Simon-Sanchez, Javier
    Castillo-Lizardo, Melissa
    Rizzu, Patrizia
    Blauwendraat, Cornelis
    Chouhan, Amit K.
    Li, Yarong
    Yogi, Puja
    Amin, Najaf
    van Duijn, Cornelia M.
    Morris, Huw R.
    Brice, Alexis
    Singleton, Andrew B.
    David, Della C.
    Nollen, Ellen A.
    Jain, Shushant
    Shulman, Joshua M.
    Heutink, Peter
    GENOME BIOLOGY, 2017, 18
  • [28] Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing
    Iris E. Jansen
    Hui Ye
    Sasja Heetveld
    Marie C. Lechler
    Helen Michels
    Renée I. Seinstra
    Steven J. Lubbe
    Valérie Drouet
    Suzanne Lesage
    Elisa Majounie
    J. Raphael Gibbs
    Mike A. Nalls
    Mina Ryten
    Juan A. Botia
    Jana Vandrovcova
    Javier Simon-Sanchez
    Melissa Castillo-Lizardo
    Patrizia Rizzu
    Cornelis Blauwendraat
    Amit K. Chouhan
    Yarong Li
    Puja Yogi
    Najaf Amin
    Cornelia M. van Duijn
    Huw R. Morris
    Alexis Brice
    Andrew B. Singleton
    Della C. David
    Ellen A. Nollen
    Shushant Jain
    Joshua M. Shulman
    Peter Heutink
    Genome Biology, 18
  • [29] Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer
    Xu, Jingxiong
    Xu, Wei
    Choi, Jiyeon
    Brhane, Yonathan
    Christiani, David C.
    Kothari, Jui
    Mckay, James
    Field, John K.
    Davies, Michael P. A.
    Liu, Geoffrey
    Amos, Christopher I.
    Hung, Rayjean J.
    Briollais, Laurent
    PLOS GENETICS, 2023, 19 (09):
  • [30] Clinical Exome Sequencing in Early-Onset Generalized Dystonia and Large-Scale Resequencing Follow-up
    Zech, Michael
    Boesch, Sylvia
    Jochim, Angela
    Weber, Sandrina
    Meindl, Tobias
    Schormair, Barbara
    Wieland, Thomas
    Lunetta, Christian
    Sansone, Valeria
    Messner, Michael
    Mueller, Joerg
    Ceballos-Baumann, Andres
    Strom, Tim M.
    Colombo, Roberto
    Poewe, Werner
    Haslinger, Bernhard
    Winkelmann, Juliane
    MOVEMENT DISORDERS, 2017, 32 (04) : 549 - 559