The power of large-scale exome sequencing

被引:0
|
作者
Linda Koch
机构
[1] Nature Reviews Genetics,
来源
Nature Reviews Genetics | 2021年 / 22卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Capturing rare protein-coding variation by whole-exome sequencing in large and diverse population samples can help identify large-effect associations and drug targets, suggest two recent publications.
引用
收藏
页码:549 / 549
相关论文
共 50 条
  • [1] The power of large-scale exome sequencing
    Koch, Linda
    NATURE REVIEWS GENETICS, 2021, 22 (09) : 549 - 549
  • [2] Inferring compound heterozygosity from large-scale exome sequencing data
    Michael H. Guo
    Laurent C. Francioli
    Sarah L. Stenton
    Julia K. Goodrich
    Nicholas A. Watts
    Moriel Singer-Berk
    Emily Groopman
    Philip W. Darnowsky
    Matthew Solomonson
    Samantha Baxter
    Grace Tiao
    Benjamin M. Neale
    Joel N. Hirschhorn
    Heidi L. Rehm
    Mark J. Daly
    Anne O’Donnell-Luria
    Konrad J. Karczewski
    Daniel G. MacArthur
    Kaitlin E. Samocha
    Nature Genetics, 2024, 56 : 152 - 161
  • [3] Inferring compound heterozygotes from large-scale exome sequencing data
    Francioli, L. C.
    Guo, M. H.
    Karczewski, K. J.
    Cummings, B. B.
    Lek, M.
    Thaker, V.
    Daly, M. J.
    Hirschhorn, J. J.
    MacArthur, D. G.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 800 - 800
  • [4] Inferring compound heterozygosity from large-scale exome sequencing data
    Guo, Michael H.
    Francioli, Laurent C.
    Stenton, Sarah L.
    Goodrich, Julia K.
    Watts, Nicholas A.
    Singer-Berk, Moriel
    Groopman, Emily
    Darnowsky, Philip W.
    Solomonson, Matthew
    Baxter, Samantha
    Tiao, Grace
    Neale, Benjamin M.
    Hirschhorn, Joel N.
    Rehm, Heidi L.
    Daly, Mark J.
    O'Donnell-Luria, Anne
    Karczewski, Konrad J.
    MacArthur, Daniel G.
    Samocha, Kaitlin E.
    NATURE GENETICS, 2024, 56 (01) : 152 - 161
  • [5] Large-Scale Exome Sequencing Identifies Novel Genes for Cognitive Function
    Chen, Chia-Yen
    Lam, Max
    Tian, Ruoyu
    Liu, Jimmy
    Tsai, Ellen
    Whelan, Christopher
    Sexton, David
    John, Sally
    Huang, Hailiang
    Ge, Tian
    Lencz, Todd
    Runz, Heiko
    BIOLOGICAL PSYCHIATRY, 2021, 89 (09) : S45 - S45
  • [6] 102 autism risk genes found in large-scale exome sequencing study
    Grennell, A. N.
    GENETICS IN MEDICINE, 2020, 22 (04) : 674 - 674
  • [7] Exome pool-seq: large-scale exome sequencing of pooled DNA samples in intellectual disability
    Popp, B.
    Ekici, A. B.
    Thiel, C.
    Hoyer, J.
    Wiesener, A.
    Kraus, C.
    Reis, A.
    Zweier, C.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2018, 26 : 342 - 342
  • [8] Expanding the genetic spectrum of inflammatory bowel disease through large-scale exome sequencing
    Zhang, Q.
    Zhu, R.
    Int Inflammatory Bowel Dis Genetics Consortium
    JOURNAL OF CROHNS & COLITIS, 2025, 19 : i41 - i42
  • [9] A large-scale whole-exome sequencing mutant resource for functional genomics in wheat
    Xiong, Hongchun
    Guo, Huijun
    Fu, Meiyu
    Xie, Yongdun
    Zhao, Linshu
    Gu, Jiayu
    Zhao, Shirong
    Ding, Yuping
    Du, Qidi
    Zhang, Jiazi
    Qiu, Lin
    Xie, Xiaomei
    Zhou, Libin
    Chen, Zhongxu
    Liu, Luxiang
    PLANT BIOTECHNOLOGY JOURNAL, 2023, 21 (10) : 2047 - 2056
  • [10] LARGE-SCALE DNA SEQUENCING
    HUNKAPILLER, T
    KAISER, RJ
    KOOP, BF
    HOOD, L
    CURRENT OPINION IN BIOTECHNOLOGY, 1991, 2 (01) : 92 - 101